{"title":"二氧化碳超临界萃取阿维菌素的研究","authors":"A. D. Ivakhnov, T. E. Skrebets","doi":"10.1134/S1990793124701033","DOIUrl":null,"url":null,"abstract":"<p>The process of supercritical fluid extraction (SCFE) of avermectin from the bacterial biomass of <i>Streptomyces avermitilis</i> with carbon dioxide is optimized by the method of a full factorial experiment using a second-order rotatable uniform plan. In the planning, the main levels chosen are a pressure of 25 MPa, a temperature of 60°C, and an extraction duration of 100 min. The analysis of the regression equation makes it possible to establish the optimal process parameters: 30 MPa, 85°C, and 133 min. In the control experiment, an extract is obtained with a yield of 13%, containing 41% avermectin. The yield of avermectin of an absolutely dry (a.d.) biomass is 5.36%, which exceeds the extraction yields obtained using organic solvents.</p>","PeriodicalId":768,"journal":{"name":"Russian Journal of Physical Chemistry B","volume":"18 7","pages":"1737 - 1744"},"PeriodicalIF":1.4000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Supercritical Fluid Extraction of Avermectin from Streptomyces avermitilis Using Carbon Dioxide\",\"authors\":\"A. D. Ivakhnov, T. E. Skrebets\",\"doi\":\"10.1134/S1990793124701033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The process of supercritical fluid extraction (SCFE) of avermectin from the bacterial biomass of <i>Streptomyces avermitilis</i> with carbon dioxide is optimized by the method of a full factorial experiment using a second-order rotatable uniform plan. In the planning, the main levels chosen are a pressure of 25 MPa, a temperature of 60°C, and an extraction duration of 100 min. The analysis of the regression equation makes it possible to establish the optimal process parameters: 30 MPa, 85°C, and 133 min. In the control experiment, an extract is obtained with a yield of 13%, containing 41% avermectin. The yield of avermectin of an absolutely dry (a.d.) biomass is 5.36%, which exceeds the extraction yields obtained using organic solvents.</p>\",\"PeriodicalId\":768,\"journal\":{\"name\":\"Russian Journal of Physical Chemistry B\",\"volume\":\"18 7\",\"pages\":\"1737 - 1744\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-01-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Physical Chemistry B\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1990793124701033\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Physical Chemistry B","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1990793124701033","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL","Score":null,"Total":0}
Supercritical Fluid Extraction of Avermectin from Streptomyces avermitilis Using Carbon Dioxide
The process of supercritical fluid extraction (SCFE) of avermectin from the bacterial biomass of Streptomyces avermitilis with carbon dioxide is optimized by the method of a full factorial experiment using a second-order rotatable uniform plan. In the planning, the main levels chosen are a pressure of 25 MPa, a temperature of 60°C, and an extraction duration of 100 min. The analysis of the regression equation makes it possible to establish the optimal process parameters: 30 MPa, 85°C, and 133 min. In the control experiment, an extract is obtained with a yield of 13%, containing 41% avermectin. The yield of avermectin of an absolutely dry (a.d.) biomass is 5.36%, which exceeds the extraction yields obtained using organic solvents.
期刊介绍：
Russian Journal of Physical Chemistry B: Focus on Physics is a journal that publishes studies in the following areas: elementary physical and chemical processes; structure of chemical compounds, reactivity, effect of external field and environment on chemical transformations; molecular dynamics and molecular organization; dynamics and kinetics of photoand radiation-induced processes; mechanism of chemical reactions in gas and condensed phases and at interfaces; chain and thermal processes of ignition, combustion and detonation in gases, two-phase and condensed systems; shock waves; new physical methods of examining chemical reactions; and biological processes in chemical physics.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
