评估健康老年人膝关节软骨厚度并分析其与患者报告结果的相关性的方案

IF 1.6 Q2 MULTIDISCIPLINARY SCIENCES
MethodsX Pub Date : 2025-01-22 DOI:10.1016/j.mex.2025.103179
Dias Tina Thomas , Charu Eapen , Atmananda S. Hegde , Prajwal Prabhudev Mane , Ajit R. Mahale
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引用次数: 0

摘要

膝骨关节炎(KOA)是一种退行性关节疾病,影响全球约2.4亿人,印度的发病率不断上升。这种疾病的进行性导致疼痛、活动能力降低和生活质量下降。尽管进行了广泛的全球研究,但缺乏针对印度人群的软骨厚度的规范数据,这对于了解疾病进展的本质至关重要。因此,本研究旨在建立健康印度成年人的标准软骨厚度值,并将这些值与膝关节损伤和骨关节炎结局评分(oos)相关联。使用超声检查,将测量100名健康人的软骨厚度。基线软骨值将与kos评分的各个领域相关联,以评估早期软骨退变及其对功能的影响。这项研究将解决印度特定数据的差距,包括KOA的早期发现和管理,以及改善临床决策以获得更好的结果和生活质量。•使用USG在健康的印度人群中建立规范的膝关节软骨厚度。•通过基于usg的软骨厚度评估,帮助在早期阶段识别KOA•使临床医生能够有效地针对康复工作,并有可能改善患者的预后和生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A protocol to assess the Knee cartilage thickness in healthy older adults and analyze its correlation with patient-reported outcomes

A protocol to assess the Knee cartilage thickness in healthy older adults and analyze its correlation with patient-reported outcomes
Knee osteoarthritis (KOA)is a degenerative joint condition affecting about 240 million people worldwide with rising incidences in India. The progressive nature of the disease leads to pain, reduced mobility, and diminished quality of life. Despite extensive global research, there is a lack of normative data on the cartilage thickness specific to the Indian population, which is crucial to understanding the nature of the disease progression. Thereby this study aims to establish normative cartilage thickness values in healthy Indian adults and correlate these values to the knee injury and osteoarthritis outcome score (KOOS). Using ultrasonography, the cartilage thickness will be measured in 100 healthy individuals. Baseline cartilage values will be linked to the various domains of the KOOS score to evaluate early cartilage degeneration and its impact on function. This research will address the gap in Indian-specific data, including early detection and management of KOA and improving clinical decision-making for better outcomes and quality of life.
  • Establish normative knee cartilage thickness in healthy Indian population using USG.
  • Helps identify KOA in early stages through USG-based cartilage thickness evaluation
  • Enables clinicians to target rehabilitation efforts effectively and potentially improve patients' outcomes and quality of life.
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来源期刊
MethodsX
MethodsX Health Professions-Medical Laboratory Technology
CiteScore
3.60
自引率
5.30%
发文量
314
审稿时长
7 weeks
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