酸性条件下伯吉斯试剂介导δ-二醇环脱水合成氧沙比环[3.2.1]辛烷-3-醇支架

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-06 DOI:10.1021/acs.orglett.4c0447310.1021/acs.orglett.4c04473

Mohamed F. Elmansy, Jose Ricardo D. dos Remedios and Richard B. Silverman*,

引用次数: 0

摘要

用Burgess试剂在温和条件下实现了δ-二醇的脱水环化，得到了一种新型的氧双环[3.2.1]辛烷-3-醇支架。基于单x射线晶体学和二维核磁共振实验，对合成的杂环化合物进行了立体化学表征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Oxabicyclo[3.2.1]octan-3-ol Scaffold via Burgess Reagent Mediated Cyclodehydration of δ-Diols under Acidic Conditions

查看原文本刊更多论文

Synthesis of Oxabicyclo[3.2.1]octan-3-ol Scaffold via Burgess Reagent Mediated Cyclodehydration of δ-Diols under Acidic Conditions

Dehydrative cyclization of δ-diols was achieved by using the Burgess reagent under mild conditions to furnish a novel oxabicyclo[3.2.1]octan-3-ol scaffold. The stereochemistry of the generated oxabicyclic compounds was assigned based on single X-ray crystallography and 2D-NMR experiments.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.