溶剂控制的SeO2、磺酰肼和炔的级联反应化学选择性获得对称的取代硒和硒的二乙烯基砜

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-03 DOI:10.1021/acs.orglett.4c0435810.1021/acs.orglett.4c04358

Yongsheng Fang, Yuting Wu, Honghong Guo, Yusen Qiu, Xinyufei Yuan and Xing Li*,

引用次数: 0

摘要

建立了一种前所未有的溶剂控制串联反应，通过无催化剂的一锅三组分方法，分别建立了结构复杂的1,2-二（（E)-1-芳基-2-芳基磺酰基乙烯基）二烷和二（(E)-1-芳基-2-芳基磺酰基）乙烯基）selanes的化学发散结构。在温和和简单的条件下，可调节和控制的合成策略对大多数底物具有良好的产率和化学选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Solvent-Controlled Cascade Reaction of SeO2, Sulfonyl Hydrazides and Alkynes for Chemoselective Access to Symmetric Divinyl Sulfones Substituted Seleniums and Diseleniums

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Solvent-Controlled Cascade Reaction of SeO2, Sulfonyl Hydrazides and Alkynes for Chemoselective Access to Symmetric Divinyl Sulfones Substituted Seleniums and Diseleniums

A solvent-controlled unprecedented tandem reaction of readily accessible SeO₂, a wide variety of sulfonyl hydrazides, and alkynes has been established for the chemodivergent construction of structurally complex 1,2-bis((E)-1-aryl-2-arylsulfonylvinyl)diselanes and bis((E)-1-aryl-2-(arylsulfonyl)vinyl)selanes via a catalyst-free one-pot three-component approach, respectively. The adjustable and controlled synthetic strategy shows good yields and chemoselectivities for most substrates under mild and simple conditions.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.