光催化自由基极性交联烯烃的烷基化反应

IF 5 1区 化学 Q1 CHEMISTRY, ORGANIC
Tiancen Bian,  and , Zuxiao Zhang*, 
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引用次数: 0

摘要

我们提出了一种用于烯烃烷基层化的光催化方法,使高效的C-C和C-N键形成,以构建对药物发现有价值的氮杂环。利用自由基-极性交叉途径,缺电子的烯烃被还原为亲电自由基,亲电自由基与富电子的烯烃反应形成亲核自由基。这些中间体氧化产生碳正离子,这些碳正离子被氮杂芳烃捕获以得到烷基层合产物。这种策略在抑制副反应的同时提高了分子的复杂性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Alkylazolation of Alkenes via Photocatalytic Radical Polar Crossover

Alkylazolation of Alkenes via Photocatalytic Radical Polar Crossover

We present a photocatalytic method for alkylamination of alkenes, enabling efficient C–C and C–N bond formation to construct aza-heterocycles valuable in drug discovery. Using a radical-polar crossover pathway, electron-deficient alkenes are reduced to electrophilic radicals, which react with electron-rich alkenes to form nucleophilic radicals. Oxidation of these intermediates yields carbocations, which are trapped by aza-heteroarenes to afford alkylaminated products. This strategy enhances molecular complexity while suppressing side reactions.

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来源期刊
Organic Letters
Organic Letters 化学-有机化学
CiteScore
9.30
自引率
11.50%
发文量
1607
审稿时长
1.5 months
期刊介绍: Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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