类黄嘌呤A的不对称全合成

IF 15.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of the American Chemical Society Pub Date : 2025-02-03 DOI:10.1021/jacs.4c17480

Fu Tang, Zhong-Chao Zhang, Zhi-Lin Song, Yuan-He Li, Zi-Hao Zhou, Jia-Jun Chen, Zhen Yang

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引用次数: 0

摘要

首次在不使用保护基团的情况下，用14步完成了类janthinoid A的不对称全合成。通过环氧化物引发的阳离子π-环化反应和Fe(ClO4)3介导的氧化级联环化反应，分别构建了反式十烷亚基和刚性氧杂环[3.2.1]辛烷基序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Asymmetric Total Synthesis of Janthinoid A

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Asymmetric Total Synthesis of Janthinoid A

The asymmetric total synthesis of janthinoid A has been accomplished for the first time in 14 steps without using a protecting group. The trans-decalin subunit and the rigid oxabicyclo[3.2.1]octane motif were constructed via an epoxide-initiated cationic π-cyclization reaction and a Fe(ClO₄)₃-mediated oxidative cascade cyclization reaction, respectively.

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来源期刊

Journal of the American Chemical Society 化学-化学综合

CiteScore

24.40

自引率

6.00%

发文量

2398

审稿时长

1.6 months

期刊介绍： The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.