{"title":"肾小球疾病患者的甲襞毛细血管镜改变。","authors":"Hend Adel , Ahmed A. Eldeeb , Fatma Hamdy","doi":"10.1016/j.reumae.2025.101803","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Glomerulonephritis is a heterogenous group of diseases which is diagnosed mainly by renal biopsy. This study aims to assess nailfold capillaroscopic changes in patients with glomerular diseases.</div></div><div><h3>Patients and methods</h3><div>This study was conducted on 50 patients with glomerular disease confirmed by renal biopsy and 50 age and sex matched healthy controls. Clinical, laboratory evaluation and nailfold capillaroscopic examination were done for all participants.</div></div><div><h3>Results</h3><div>Lupus nephritis was the most common pathological type among glomerulonephritis group [17 (34%)], followed by focal segmental glomerulosclerosis [9 (18%)]. Tortuous capillaries were significantly higher in patients with primary glomerular diseases compared to healthy persons (92.9% vs 58%, <em>P</em> <!--><<!--> <!-->0.001). The diameter was significantly lower in patients with primary glomerular diseases compared to healthy control group (15.6<!--> <!-->μm vs 18.9<!--> <!-->μm, <em>P</em> <!-->=<!--> <!-->0.001). Subpapillary venous plexus (28.6% vs 6%, <em>P</em> <!-->=<!--> <!-->0.02) and capillary microhemorrhage (32% vs 0%, <em>P</em> <!--><<!--> <!-->0.001) were significantly more frequent in patients with primary glomerular diseases compared to the control group. Patients with lupus nephritis had higher capillary diameter (19.5 vs 15.6<!--> <!-->μm, <em>P</em> <!-->=<!--> <!-->0.02), width (55.6 vs 44<!--> <!-->μm, <em>P</em> <!-->=<!--> <!-->0.003) and microhemorrhage (64.7% vs 32%, <em>P</em> <!-->=<!--> <!-->0.03) compared to patients with primary glomerulonephritis. There was a statistically significant difference as regard diameter (<em>P</em> <!-->=<!--> <!-->0.005) and length (<em>P</em> <!-->=<!--> <!-->0.02) between different classes of lupus nephritis.</div></div><div><h3>Conclusion</h3><div>More tortious capillaries and lower capillary diameter were found in patients with primary glomerular disease compared to healthy persons. Lupus nephritis patients had more dilated capillaries and more capillary microhemorrhage compared to primary glomerulonephritis patients.</div></div>","PeriodicalId":94193,"journal":{"name":"Reumatologia clinica","volume":"21 1","pages":"Article 101803"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nailfold capillaroscopic changes in patients with glomerular diseases\",\"authors\":\"Hend Adel , Ahmed A. Eldeeb , Fatma Hamdy\",\"doi\":\"10.1016/j.reumae.2025.101803\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction and objectives</h3><div>Glomerulonephritis is a heterogenous group of diseases which is diagnosed mainly by renal biopsy. This study aims to assess nailfold capillaroscopic changes in patients with glomerular diseases.</div></div><div><h3>Patients and methods</h3><div>This study was conducted on 50 patients with glomerular disease confirmed by renal biopsy and 50 age and sex matched healthy controls. Clinical, laboratory evaluation and nailfold capillaroscopic examination were done for all participants.</div></div><div><h3>Results</h3><div>Lupus nephritis was the most common pathological type among glomerulonephritis group [17 (34%)], followed by focal segmental glomerulosclerosis [9 (18%)]. Tortuous capillaries were significantly higher in patients with primary glomerular diseases compared to healthy persons (92.9% vs 58%, <em>P</em> <!--><<!--> <!-->0.001). The diameter was significantly lower in patients with primary glomerular diseases compared to healthy control group (15.6<!--> <!-->μm vs 18.9<!--> <!-->μm, <em>P</em> <!-->=<!--> <!-->0.001). Subpapillary venous plexus (28.6% vs 6%, <em>P</em> <!-->=<!--> <!-->0.02) and capillary microhemorrhage (32% vs 0%, <em>P</em> <!--><<!--> <!-->0.001) were significantly more frequent in patients with primary glomerular diseases compared to the control group. Patients with lupus nephritis had higher capillary diameter (19.5 vs 15.6<!--> <!-->μm, <em>P</em> <!-->=<!--> <!-->0.02), width (55.6 vs 44<!--> <!-->μm, <em>P</em> <!-->=<!--> <!-->0.003) and microhemorrhage (64.7% vs 32%, <em>P</em> <!-->=<!--> <!-->0.03) compared to patients with primary glomerulonephritis. There was a statistically significant difference as regard diameter (<em>P</em> <!-->=<!--> <!-->0.005) and length (<em>P</em> <!-->=<!--> <!-->0.02) between different classes of lupus nephritis.</div></div><div><h3>Conclusion</h3><div>More tortious capillaries and lower capillary diameter were found in patients with primary glomerular disease compared to healthy persons. Lupus nephritis patients had more dilated capillaries and more capillary microhemorrhage compared to primary glomerulonephritis patients.</div></div>\",\"PeriodicalId\":94193,\"journal\":{\"name\":\"Reumatologia clinica\",\"volume\":\"21 1\",\"pages\":\"Article 101803\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reumatologia clinica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2173574325000139\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reumatologia clinica","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2173574325000139","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
简介与目的：肾小球肾炎是一种异质性疾病，主要通过肾活检诊断。本研究旨在评估肾小球疾病患者的甲襞毛细血管镜改变。患者和方法：本研究对50例经肾活检证实的肾小球疾病患者和50例年龄和性别匹配的健康对照进行了研究。对所有参与者进行临床、实验室评估和甲襞毛细血管镜检查。结果：狼疮性肾炎是肾小球肾炎组中最常见的病理类型[17例（34%）]，其次是局灶节段性肾小球硬化[9例（18%）]。原发性肾小球疾病患者毛细血管扭曲率明显高于健康人（92.9% vs 58%）。结论：原发性肾小球疾病患者毛细血管扭曲率明显高于健康人，毛细血管直径明显小于健康人。与原发性肾小球肾炎患者相比，狼疮性肾炎患者毛细血管扩张和毛细血管微出血较多。
Nailfold capillaroscopic changes in patients with glomerular diseases
Introduction and objectives
Glomerulonephritis is a heterogenous group of diseases which is diagnosed mainly by renal biopsy. This study aims to assess nailfold capillaroscopic changes in patients with glomerular diseases.
Patients and methods
This study was conducted on 50 patients with glomerular disease confirmed by renal biopsy and 50 age and sex matched healthy controls. Clinical, laboratory evaluation and nailfold capillaroscopic examination were done for all participants.
Results
Lupus nephritis was the most common pathological type among glomerulonephritis group [17 (34%)], followed by focal segmental glomerulosclerosis [9 (18%)]. Tortuous capillaries were significantly higher in patients with primary glomerular diseases compared to healthy persons (92.9% vs 58%, P < 0.001). The diameter was significantly lower in patients with primary glomerular diseases compared to healthy control group (15.6 μm vs 18.9 μm, P = 0.001). Subpapillary venous plexus (28.6% vs 6%, P = 0.02) and capillary microhemorrhage (32% vs 0%, P < 0.001) were significantly more frequent in patients with primary glomerular diseases compared to the control group. Patients with lupus nephritis had higher capillary diameter (19.5 vs 15.6 μm, P = 0.02), width (55.6 vs 44 μm, P = 0.003) and microhemorrhage (64.7% vs 32%, P = 0.03) compared to patients with primary glomerulonephritis. There was a statistically significant difference as regard diameter (P = 0.005) and length (P = 0.02) between different classes of lupus nephritis.
Conclusion
More tortious capillaries and lower capillary diameter were found in patients with primary glomerular disease compared to healthy persons. Lupus nephritis patients had more dilated capillaries and more capillary microhemorrhage compared to primary glomerulonephritis patients.
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