贫血对雌性大鼠青春期开始时间的影响。

IF 1.8 4区 医学 Q4 TOXICOLOGY
Mariko Shimada, Yoshinori Hosokawa, Ryo Ihara, Keiko Ogata, Katsumasa Iwashita, Ryoko Matsuyama, Hiroyuki Asano
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引用次数: 0

摘要

在毒性研究中,达到阴道通畅是雌性动物青春期开始的终点。人们普遍认为,某些具有内分泌调节作用的物质可以影响雌性大鼠的青春期时间,而与内分泌机制无关的因素,如营养不良和压力,也可以影响青春期的开始。一些流行病学研究也表明,贫血与女性青春期延迟之间存在联系,然而,在实验动物中,关于血液学变化与女性青春期延迟之间的关系知之甚少。本研究旨在探讨青春期前贫血对雌性大鼠青春期发育及生殖器官的影响。在这项研究中,通过从颈静脉抽取一定量的血液或通过腹腔注射苯肼(一种众所周知的溶血性贫血诱导剂)来诱导贫血。结果,两个治疗组都表现出短暂性贫血,其特征是血红蛋白水平比对照组降低了约20-35%。贫血雌性大鼠出生后各天体重变化不明显,对雌雄分化后生殖器官的重量和组织病理学无影响,但阴道开口年龄延迟,阴道开口体重高于对照组相同参数。这些结果表明,青春期前女性的贫血可能导致青春期发作的延迟。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effects of anemia on the timing of pubertal onset in female rats.

Attainment of vaginal patency is an endpoint for the onset of puberty in female animals in toxicity studies. It is widely acknowledged that certain substances with endocrine-modulating effects can influence the timing of puberty in female rats and that factors unrelated to endocrine mechanisms, such as malnutrition and stress, can also affect pubertal onset. Some epidemiological studies have also suggested a link between anemia and delay in pubertal onset in women, however, little is known regarding the relation between hematological changes and female pubertal onset in experimental animals. The purpose of this study was to examine the effects of anemia during the prepubertal period on pubertal onset and reproductive organs in female rats. In this study, anemia was induced by drawing a certain amount of blood from the jugular vein or by intraperitoneal administration of phenylhydrazine, a well-known inducer of hemolytic anemia. As a result, both treatment groups showed a transient anemia characterized by an approximately 20-35% decrease in hemoglobin levels compared to the control group. Anemia in these female rats produced no obvious changes in body weight on each postnatal day and had no effect on the weights and histopathology of reproductive organs after sexual differentiation, but the age at vaginal opening (VO) was delayed and the body weight at VO was higher than the same parameters in the control group. These results suggest that anemia in prepubertal females could cause a delay in pubertal onset.

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来源期刊
CiteScore
3.20
自引率
5.00%
发文量
53
审稿时长
4-8 weeks
期刊介绍: The Journal of Toxicological Sciences (J. Toxicol. Sci.) is a scientific journal that publishes research about the mechanisms and significance of the toxicity of substances, such as drugs, food additives, food contaminants and environmental pollutants. Papers on the toxicities and effects of extracts and mixtures containing unidentified compounds cannot be accepted as a general rule.
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