阿非利赛普2mg治疗新生血管性年龄相关性黄斑变性的治疗间隔进展和依从性观察和计划方案

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI:10.1007/s40123-025-01095-1

Leyla Turan, Andreas Arnold-Vangsted, Morten la Cour, Delila Hodzic-Hadzibegovic, Javad N Hajari, Oliver N Klefter, Miklos Schneider, Yousif Subhi

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引用次数: 0

摘要

导论：抗血管内皮生长因子（VEGF）治疗新生血管性年龄相关性黄斑变性（AMD）的治疗负担可以通过观察和计划（O&P）方案减轻，该方案允许个体化治疗，同时减少注射次数和评估就诊次数。在这项研究中，我们通过个体随访评估了治疗间隔调整的详细特征，并在欧洲最大的中心之一的现实环境中评估了对O&P方案的依从性。方法：这是一项回顾性队列研究，treatment-naïve眼部新生血管性AMD患者在完成加载剂量后持续渗出，在O&P方案中玻璃体内注射2mg阿布西普。我们从总共5次随访中评估了治疗间隔调整和O&P方案依从性的决定。就诊和决定治疗间隔的数据从治疗数据库中提取。结果：共有561只眼睛符合本研究的条件。治疗间隔从4周（负荷剂量）逐渐增加到4周至12周的广泛间隔分布，在第5次随访时，24.9%的患者未接受任何治疗。在第5次随访时，共有209只眼（49.5%）（第5次随访时共有422只眼）遵守了治疗算法。结论：在O&P治疗方案中，阿非利西普2mg会导致治疗间隔时间的变化，部分眼可能出现治疗过度。很大一部分眼睛偏离了预期的O&P治疗方案。我们的研究有助于理解个性化治疗方案对现实世界的影响。

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Treatment Interval Progression and Adherence to Observe-and-Plan Regimen for Neovascular Age-Related Macular Degeneration Treated with Aflibercept 2 mg.

Introduction: Treatment burden of anti-vascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration (AMD) can be reduced with the Observe-and-Plan (O&P) regimen, which allows for an individualized treatment while reducing the number of injections and assessment visits. In this study, we evaluate detailed characteristics of treatment interval adjustment through individual follow-ups and evaluate adherence to the O&P regimen in a real-world setting in one of the largest centers in Europe.

Methods: This was a retrospective cohort study of treatment-naïve eyes with neovascular AMD that were treated with intravitreal aflibercept 2 mg in an O&P regimen who had persisting exudation after completion of loading dose. We evaluated decisions on adjustment of treatment intervals and adherence to the O&P regimen from a total of 5 follow-up visits. Data from visits and decision on treatment intervals were extracted from a treatment database.

Results: A total of 561 eyes were eligible for this study. Treatment intervals gradually increased from a 4-weeks interval (loading dose) to a wide distribution of intervals from 4-weeks to 12-weeks, and at the 5th follow-up 24.9% were followed without any treatment. In total, 209 eyes (49.5%) at the 5th follow-up (of 422 eyes present at the 5th follow-up) adhered to the treatment algorithm.

Conclusion: Aflibercept 2 mg in an O&P treatment regimen leads to a variety of treatment intervals, and some eyes may be overtreated. An important proportion of eyes deviate from the intended O&P treatment regimen. Our study contributes to understanding real-world implications of personalized treatment regimens.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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