Juan Camilo Benítez Agudelo , Edgar Navarro Lechuga , Karen Cecilia Flórez Lozano , Ernesto Barceló Martínez , Carlos Mario de Oro Aguado
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The clinical history shows that 47.9% (204) had a clinical history of hypertension, followed by symptoms of depression with 37.6% (160) and a tendency to isolation with 28.6% (122). Information on neuropsychological markers and associated factors was obtained through a neuropsychological assessment protocol.</div></div><div><h3>Results</h3><div>In the aMCI group, the domains of: focused care (OR: 10.74 95% CI 3.386-34.11) were found as significantly associated factors with respect to subjects without apparent pathology; episodic memory (storage) (OR: 36.52 95% CI 15.14-88.05) and denomination (OR: 5.043 95% CI 1.816-14.00).</div></div><div><h3>Conclusions</h3><div>Focused attention, episodic memory (storage) and naming become neuropsychological markers associated with aMCI; likewise, social isolation is shown to be a factor associated with aMCI when compared to subjects with non-amnestic predominant mild cognitive impairment (anMCI).</div></div>","PeriodicalId":39958,"journal":{"name":"Revista Espanola de Geriatria y Gerontologia","volume":"60 2","pages":"Article 101620"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Marcadores neuropsicológicos y factores asociados al deterioro cognitivo leve amnésico\",\"authors\":\"Juan Camilo Benítez Agudelo , Edgar Navarro Lechuga , Karen Cecilia Flórez Lozano , Ernesto Barceló Martínez , Carlos Mario de Oro Aguado\",\"doi\":\"10.1016/j.regg.2024.101620\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Mild amnestic cognitive impairment (aMCI) is a syndrome in which there are cognitive deficits characterized by memory complaints, with the endophenotype with the highest rate of conversion to dementia, especially the Alzheimer type. The objective of the study was to establish neuropsychological markers and factors associated with aMCI.</div></div><div><h3>Methods</h3><div>Transversal descriptive study with case and control analysis, with a sample of 426 subjects selected by non-probabilistic convenience sampling. The average age was 58.8<!--> <!-->±<!--> <!-->5.5 years, 57.3% (244) of the sample were women, and 184 subjects (43.2%) had university studies. The clinical history shows that 47.9% (204) had a clinical history of hypertension, followed by symptoms of depression with 37.6% (160) and a tendency to isolation with 28.6% (122). 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引用次数: 0
摘要
背景:轻度遗忘性认知障碍(aMCI)是一种以记忆抱怨为特征的认知缺陷综合征,其内表型转化为痴呆的比例最高,尤其是阿尔茨海默氏型。本研究的目的是建立与aMCI相关的神经心理学标志物和因素。方法:采用非概率方便抽样法,采用病例与对照相结合的横向描述性研究方法,抽取426名被试。平均年龄58.8±5.5岁,女性占57.3%(244人),大学学历184人(43.2%)。临床病史中,有高血压病史的占47.9%(204人),有抑郁症状的占37.6%(160人),有孤立倾向的占28.6%(122人)。通过神经心理学评估方案获得神经心理学标志物和相关因素的信息。结果:在aMCI组中,集中护理领域(OR: 10.74 95% CI 3.386-34.11)被发现是与无明显病理的受试者显著相关的因素;情景记忆(存储)(OR: 36.52 95% CI 15.14-88.05)和名称(OR: 5.043 95% CI 1.816-14.00)。结论:注意力集中、情景记忆(储存)和命名是与aMCI相关的神经心理指标;同样,与非健忘症为主的轻度认知障碍(anMCI)受试者相比,社会孤立被证明是与aMCI相关的一个因素。
Marcadores neuropsicológicos y factores asociados al deterioro cognitivo leve amnésico
Background
Mild amnestic cognitive impairment (aMCI) is a syndrome in which there are cognitive deficits characterized by memory complaints, with the endophenotype with the highest rate of conversion to dementia, especially the Alzheimer type. The objective of the study was to establish neuropsychological markers and factors associated with aMCI.
Methods
Transversal descriptive study with case and control analysis, with a sample of 426 subjects selected by non-probabilistic convenience sampling. The average age was 58.8 ± 5.5 years, 57.3% (244) of the sample were women, and 184 subjects (43.2%) had university studies. The clinical history shows that 47.9% (204) had a clinical history of hypertension, followed by symptoms of depression with 37.6% (160) and a tendency to isolation with 28.6% (122). Information on neuropsychological markers and associated factors was obtained through a neuropsychological assessment protocol.
Results
In the aMCI group, the domains of: focused care (OR: 10.74 95% CI 3.386-34.11) were found as significantly associated factors with respect to subjects without apparent pathology; episodic memory (storage) (OR: 36.52 95% CI 15.14-88.05) and denomination (OR: 5.043 95% CI 1.816-14.00).
Conclusions
Focused attention, episodic memory (storage) and naming become neuropsychological markers associated with aMCI; likewise, social isolation is shown to be a factor associated with aMCI when compared to subjects with non-amnestic predominant mild cognitive impairment (anMCI).
期刊介绍:
Una revista de gran prestigio por sus artículos originales de investigación y revisiones. Permite cubrir todas las áreas de la medicina pero siempre desde la atención al paciente anciano, y está presente en los más reconocidos índices internacionales.