强烈的生活方式改变对阿尔茨海默病引起的轻度认知障碍或早期痴呆进展的影响：需要严谨

IF 7.9 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's Research & Therapy Pub Date : 2025-02-01 DOI:10.1186/s13195-024-01621-6

Joshua D Grill, Daniel Gillen

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引用次数: 0

摘要

我们考虑到Ornish和他的同事最近发表的文章，以及对介入性临床试验的严格期望。我们认为，生活方式干预试验应该争取与药物试验同样的严谨性，并强调在本例中提高严谨性的机会，特别是在设计、数据分析和发表本研究和其他生活方式干预研究的结果方面。

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Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: the need for rigor.

We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials. We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve rigor in this example, particularly in design, data analysis, and publication of results for this and other lifestyle intervention studies.

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来源期刊

Alzheimer's Research & Therapy 医学-神经病学

CiteScore

13.10

自引率

3.30%

发文量

172

审稿时长

>12 weeks

期刊介绍： Alzheimer's Research & Therapy is an international peer-reviewed journal that focuses on translational research into Alzheimer's disease and other neurodegenerative diseases. It publishes open-access basic research, clinical trials, drug discovery and development studies, and epidemiologic studies. The journal also includes reviews, viewpoints, commentaries, debates, and reports. All articles published in Alzheimer's Research & Therapy are included in several reputable databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, MEDLINE, PubMed, PubMed Central, Science Citation Index Expanded (Web of Science) and Scopus.