羧酸的直接C1同源化：由吖啶催化实现的自由基方法

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2025-02-12 DOI:10.1039/d4qo02442g

Zakhar M. Rubanov , Vitalij V. Levin , Alexander D. Dilman

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引用次数: 0

摘要

描述了羧酸的光催化C1同源化。转换是在一个方便的单锅过程中完成的。该反应的关键步骤是在双吖啶/癸烯酸光催化体系下，在乙基乙醛酸甲酰腙上进行脱羧自由基加成反应。所得到的肼中间体通过碱处理很容易转化为同源羧酸酯。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Direct C1 homologation of carboxylic acids: free radical approach enabled by acridine catalysis†

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Direct C1 homologation of carboxylic acids: free radical approach enabled by acridine catalysis†

A photocatalytic C1 homologation of carboxylic acids is described. The transformation is performed in a convenient one-pot procedure. The key step is decarboxylative radical addition to a tosylhydrazone derived from ethyl glyoxylate, which is mediated by a dual acridine/decatungstate photocatalytic system. The resulting hydrazide intermediate is easily converted to the homologated carboxylic ester by treatment with a base.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

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