导向基团使能钌催化萘及相关碳环芳烃的不对称加氢反应。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-14 Epub Date: 2025-01-31 DOI:10.1021/acs.orglett.5c00014

Mu-Wang Chen, Yi-Xuan Ding, Yong-Gui Zhou

引用次数: 0

摘要

在芳香碳环中，非对称萘的高区域选择性和对映选择性加氢一直是不对称催化中的一个长期挑战。在此，我们报道了一个酰胺定向不对称加氢的不对称萘与钌催化剂高达99% ee。该方法还成功地应用于多环芳烃的不对称加氢反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Directing Group Enabled Ruthenium-Catalyzed Asymmetric Hydrogenation of Naphthalenes and Related Carbocyclic Aromatics.

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Directing Group Enabled Ruthenium-Catalyzed Asymmetric Hydrogenation of Naphthalenes and Related Carbocyclic Aromatics.

Among the aromatic carbocyclic rings, the highly regio- and enantioselective hydrogenation of nonsymmetrical naphthalenes has remained a long-standing challenge in asymmetric catalysis. Herein, we reporte an amide-directed asymmetric hydrogenation of nonsymmetrical naphthalenes with a ruthenium catalyst with up to 99% ee. This strategy was also successfully applied in the asymmetric hydrogenation of polycyclic aromatic hydrocarbons.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.