质子治疗的可变相对生物有效性模型的线性逼近。

IF 3.4 Q2 ONCOLOGY

Physics and Imaging in Radiation Oncology Pub Date : 2025-01-01 DOI:10.1016/j.phro.2024.100691

Dirk Wagenaar, Johannes A. Langendijk, Stefan Both

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引用次数: 0

摘要

计算20例脑癌患者的McNamara （MCN）和Wedenberg (WED) RBE加权剂量（DRBE）、剂量和剂量加权平均LET （LETd）。对每个RBE模型进行线性近似，以使其与临床相关剂量学参数最一致。对20名头颈癌和20名乳腺癌患者进行了额外的评估。α/β值≥1.0 Gy时，MCN和WED的拟合R2分别为≥0.94和≥0.91。在这项工作中得到的图可以用来转换从临床数据得到的RBE-LET斜率到MCN或WED模型中的α/β值。

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Linear approximation of variable relative biological effectiveness models for proton therapy

The McNamara (MCN) and Wedenberg (WED) RBE weighted dose (D_RBE), dose and dose-weighted average LET (LET_d) were calculated in twenty brain cancer patients. A linear approximation was made for each RBE model to give best agreement to clinically relevant dosimetric parameters. Additional evaluations were done on twenty head and neck and twenty breast cancer patients.The R² of the fits was ≥0.94 and ≥0.91 for MCN and WED respectively for α/β values ≥1.0 Gy. The graphs derived in this work can be used to convert RBE-LET slopes derived from clinical data to α/β values in the MCN or WED models.

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来源期刊

Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation

CiteScore

5.30

自引率

18.90%

发文量

审稿时长

6 weeks