Anna Sather, Molly Marshall, Raghav Murthy, Jacqueline M. Lamour, Christyn Chase, Neha Bansal
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引用次数: 0
摘要
本研究旨在评估使用SherpaPakCardiac Transport System保存供体心脏的儿童心脏移植患者的临床结果。方法：纳入并描述2020年1月至2024年6月期间在本中心接受心脏移植的所有儿科患者。计算血管活性肌力评分（VIS）。该队列根据受者诊断分为两组（心肌病vs先天性心脏病[CHD]）。他们根据人口统计学、手术细节和术后结果进行比较。分类变量采用χ2和Fisher精确检验，连续变量采用Mann-Whitney U检验或t检验。结果：共纳入18例患者。中位受体年龄为11.9岁（IQR: 2.5, 13.9）。一半有心肌病，中位总缺血时间为236分钟（IQR: 211.5, 283.5）。两组比较，尽管冠心病组的中位循环停搏时间和旁路次数明显延长，但VIS和原发性移植物功能障碍（PGD）无显著差异（p < 0.05）。3例患者出现早期排斥反应（均伴有冠心病），但无死亡。结论：SherpaPak心脏转运系统为儿童心脏移植患者提供了安全的结果，包括那些患有复杂冠心病的患者。需要进一步的多机构和登记研究来评估这种方法在儿童心脏移植中的应用。
SherpaPak Cardiac Transport System: Experience in Pediatric Heart Transplantation
Introduction
The present study aimed to assess the clinical outcomes of pediatric heart transplant patients whose donor hearts were preserved with the SherpaPakCardiac Transport System.
Methods
All pediatric patients undergoing heart transplantation at our center between January 2020 and June 2024 were included and described. Vasoactive inotropic score (VIS) was calculated. The cohort was divided into two groups by recipient diagnoses (cardiomyopathy vs. congenital heart disease [CHD]). They were compared based on demographics, operative details, and postoperative outcomes. The χ2 and Fisher exact tests were used for categorical variables and the Mann–Whitney U test or t-test for continuous variables.
Results
A total of 18 patients were included. The median recipient age was 11.9 years (IQR: 2.5, 13.9). Half had cardiomyopathy, median total ischemic time was 236 min (IQR: 211.5, 283.5). Upon comparing the two groups, there were no significant differences observed in VIS or primary graft dysfunction (PGD) even though the median circulatory arrest time and bypass times were significantly longer in the CHD group (p < 0.05). Three patients experienced early rejection (all with CHD), but there was no mortality.
Conclusions
The SherpaPak Cardiac Transport System provides safe outcomes for pediatric heart transplant patients, including those with complex CHD. Further multi-institutional and registry studies are needed to evaluate this method for pediatric heart transplantation.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
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