细胞外囊泡:阿尔茨海默病的一种有前途的治疗方法。

Shima Mehrabadi
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引用次数: 0

摘要

细胞外囊泡(EVs)是由各种细胞类型分泌的纳米级膜状颗粒,在细胞间通讯中起关键作用。它们独特的特性和向靶细胞输送生物活性物质的卓越能力,使它们成为治疗包括阿尔茨海默病(AD)在内的各种疾病的有希望的工具。AD是一种破坏性的神经退行性疾病,其特征是进行性认知能力下降和神经病理特征,如淀粉样斑块和神经原纤维缠结。尽管进行了广泛的研究,但目前还没有针对AD的疾病改善疗法。然而,由于ev具有穿越血脑屏障、传递生物活性货物和调节神经炎症的能力,因此它已成为AD的潜在治疗剂。本文综述了目前关于EVs在AD中的作用的知识,并讨论了它们作为治疗方法的潜力。它涵盖了作用机制,潜在的治疗靶点,以及基于ev的AD治疗的挑战和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extracellular Vesicles: A Promising Therapeutic Approach to Alzheimer's Disease.

Extracellular vesicles (EVs) are nano-sized membranous particles that are secreted by various cell types and play a critical role in intercellular communication. Their unique properties and remarkable ability to deliver bioactive cargo to target cells have made them promising tools in the treatment of various diseases, including Alzheimer's disease (AD). AD is a devastating neurodegenerative disease characterized by progressive cognitive decline and neuropathological hallmarks, such as amyloid-beta plaques and neurofibrillary tangles. Despite extensive research, no disease-modifying therapy for AD is currently available. However, EVs have emerged as a potential therapeutic agent in AD due to their ability to cross the blood-brain barrier, deliver bioactive cargo, and modulate neuroinflammation. This review provides a comprehensive overview of the current knowledge on the role of EVs in AD and discusses their potential as a therapeutic approach. It covers the mechanisms of action, potential therapeutic targets, and challenges and limitations of EV-based therapies for AD.

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