BATF在免疫细胞分化和自身免疫性疾病中的作用。

IF 9.5 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarker Research Pub Date : 2025-01-29 DOI:10.1186/s40364-025-00733-x

Xiaomeng Wang, Yue Hong, Jinmei Zou, Bo Zhu, Chao Jiang, Liwei Lu, Jie Tian, Jing Yang, Ke Rui

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引用次数: 0

摘要

碱性亮氨酸拉链转录因子（Basic Leucine Zipper transcription factor， BATF）是激活蛋白-1 （Activator protein -1, AP-1）转录因子家族的一员，通过参与蛋白质相互作用和与DNA的结合介导免疫细胞的多种生物学功能。近年来的研究表明，BATF不仅在先天性和适应性免疫反应中起着关键作用，而且在各种免疫细胞的分化和功能中起着至关重要的作用。有证据表明，BATF与过敏性疾病、移植物抗宿主病、肿瘤和自身免疫性疾病的发生和进展有关。本文综述了BATF在先天免疫细胞和适应性免疫细胞的发育和功能中的作用，以及其在自身免疫性疾病发展中的免疫调节作用，以期加深对自身免疫性疾病发病机制的认识，促进新的治疗策略的开发。

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The role of BATF in immune cell differentiation and autoimmune diseases.

As a member of the Activator Protein-1 (AP-1) transcription factor family, the Basic Leucine Zipper Transcription Factor (BATF) mediates multiple biological functions of immune cells through its involvement in protein interactions and binding to DNA. Recent studies have demonstrated that BATF not only plays pivotal roles in innate and adaptive immune responses but also acts as a crucial factor in the differentiation and function of various immune cells. Lines of evidence indicate that BATF is associated with the onset and progression of allergic diseases, graft-versus-host disease, tumors, and autoimmune diseases. This review summarizes the roles of BATF in the development and function of innate and adaptive immune cells, as well as its immunoregulatory effects in the development of autoimmune diseases, which may enhance the current understanding of the pathogenesis of autoimmune diseases and facilitate the development of new therapeutic strategies.

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来源期刊

Biomarker Research Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

15.80

自引率

1.80%

发文量

审稿时长

10 weeks

期刊介绍： Biomarker Research, an open-access, peer-reviewed journal, covers all aspects of biomarker investigation. It seeks to publish original discoveries, novel concepts, commentaries, and reviews across various biomedical disciplines. The field of biomarker research has progressed significantly with the rise of personalized medicine and individual health. Biomarkers play a crucial role in drug discovery and development, as well as in disease diagnosis, treatment, prognosis, and prevention, particularly in the genome era.