阿根廷低剂量计算机断层扫描筛查肺癌的预算影响。

IF 1.5 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-06-01 Epub Date: 2025-01-30 DOI:10.1080/14737167.2025.2460523

Constanza Silvestrini, Lucas Perelli, Andrea Alcaraz, Natalia Espinola, Fernando Argento

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引用次数: 0

摘要

背景：肺癌（LC）是阿根廷癌症死亡的主要原因。作为早期发现和降低LC死亡率的筛查方法，低剂量计算机断层扫描（LDCT）已被证明比胸部x线摄影更有效。本研究估计了在阿根廷对年龄在55-74岁、吸烟至少30包年的个体实施年度LDCT筛查的预算影响。研究设计和方法：从阿根廷卫生系统的角度开发了动态队列的预算影响模型，考虑LC事件，患病率和死亡概率，区分疾病阶段和生存年限。模型参数来源于文献和官方数据库，成本以2023美元表示。结果：在阿根廷，726,420人有资格进行年度LC筛查。当前方案的平均年度预算为196,611,452美元，预计方案为207,439,560美元，由于LDCT假阳性和筛查成本增加，导致成本增加5.20%。每个成员每月的预算影响为0.019美元，略高于0.015美元的估计阈值。结论：引入LDCT进行LC筛查增加了阿根廷卫生系统预算，但改善了早期疾病检测。

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Budget impact of low-dose computed tomography screening for lung cancer in Argentina.

Background: Lung cancer (LC) is a leading cause of cancer mortality in Argentina. Low-dose computed tomography (LDCT) had demonstrated higher efficacy than chest radiography as a screening method for early detection and reducing LC mortality. This study estimates the Budget Impact of implementing annual LDCT screening for individuals aged 55-74 with at least 30 pack-years of smoking in Argentina.

Research design and methods: A budgetary impact model for a dynamic cohort was developed from the Argentine health system's perspective, accounting for LC incidents, prevalents and death probability, distinguishing by disease stage and survival years. Model parameters were sourced from literature and official databases, with costs expressed in 2023 USD.

Results: In Argentina, 726,420 individuals were eligible for annual LC screening. The average annual budget was USD 196,611,452 in the current scenario and USD 207,439,560 in the projected scenario, leading to a 5.20% incremental cost due to more false positives in LDCT and screening costs. The budget impact per member per month was USD 0.019, slightly above the estimated threshold of USD 0.015.

Conclusions: The introduction of LDCT for LC screening increased the health system budget in Argentina but improved early disease detection.

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来源期刊

Expert Review of Pharmacoeconomics & Outcomes Research HEALTH CARE SCIENCES & SERVICES-PHARMACOLOGY & PHARMACY

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Pharmacoeconomics & Outcomes Research (ISSN 1473-7167) provides expert reviews on cost-benefit and pharmacoeconomic issues relating to the clinical use of drugs and therapeutic approaches. Coverage includes pharmacoeconomics and quality-of-life research, therapeutic outcomes, evidence-based medicine and cost-benefit research. All articles are subject to rigorous peer-review. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.