非对映选择性可见光诱导1,6-炔与s -芳基三氟甲烷磺硫酸酯（TTSA）的自由基级联三氟甲基化/硫化/环化

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2025-02-12 DOI:10.1039/d4qo01597e

Yuhao Jiang , Jiapeng Sun , Qi Hu , Jianmin Huang , Yingming Song , Hua Cao , Yue Yu

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引用次数: 0

摘要

在光催化条件下，一种新型的高活性三氟甲基化/硫化试剂s -芳基三氟甲烷磺硫酸酯（TTSA）与多种1,6-炔反应，得到了高产量、高非对映选择性的三氟甲基化二氢呋喃-2- 1或吡咯烷-2- 1衍生物。在这个自由基级联过程中，一步形成了C-S、C-C和C-CF3三个新的化学键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Diastereoselective visible-light-induced radical cascade trifluoromethylation/sulfuration/cyclization of 1,6-enynes with S-aryl trifluoromethanesulfonothioate (TTSA)†

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Diastereoselective visible-light-induced radical cascade trifluoromethylation/sulfuration/cyclization of 1,6-enynes with S-aryl trifluoromethanesulfonothioate (TTSA)†

Under photocatalytic conditions, a novel and highly reactive trifluoromethylating/sulfurating reagent, S-aryl trifluoromethanesulfonothioate (TTSA), was reacted with a variety of 1,6-enynes, affording sulfurated and trifluoromethylated dihydrofuran-2-one or pyrrolidin-2-one derivates in great yields with high diastereoselectivities. In this radical cascade process, three new chemical bonds including C–S, C–C, and C–CF₃ bonds were formed in one step.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

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