不同睡眠特征与龋病的因果关系：一项双向孟德尔随机研究。

IF 2 3区心理学 Q3 PSYCHOLOGY, CLINICAL

International Journal of Behavioral Medicine Pub Date : 2025-01-27 DOI:10.1007/s12529-025-10350-5

Dan Zhou, Zehan Zhang, Jianxing Zhang, Heqing Lai, Qing Zhou, Chao Pei

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引用次数: 0

摘要

背景：龋病是一种重要的口腔常见病。近年来，研究者越来越关注不良睡眠习惯对龋病发生发展的影响，这引起了我们对研究睡眠与龋病的相关性和因果关系的兴趣。方法：本研究采用连锁不平衡评分（Linkage disequilibrium score， LDSC）回归方法寻找不同睡眠特征与DC之间的遗传相关性，采用双向孟德尔随机化（双向孟德尔随机化，MR）方法探讨其因果关系。MR的主要分析方法为方差反加权法，结果评价采用优势比（OR）和95%置信区间（95% CI）。结果：经LDSC回归分析，睡眠类型、打盹、失眠、睡眠时间与DC存在遗传相关性（P = 0.002, P = 0.026, P = 7.233E-09, P = 0.012）。然而，当使用TSMR方法时，时间类型、打瞌睡、失眠、睡眠时间与DC之间没有明显的因果关系（P = 0.832, P = 0.129, P = 0.822, P = 0.644）。通过使用额外的验证数据集进一步证实了这一结果。结论：我们的研究没有发现睡眠特征和DC之间的因果关系。

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Causal Relationship Between Different Sleep Traits and Dental Caries: A Bidirectional Mendelian Randomization Study.

Background: Dental caries (DC) is a significant common disease of the oral cavity. Recently, researchers have focused more on the impact of poor sleep habits on the incidence and development of DC, which aroused our interest in the study of the correlation and causal relationship between sleep and dental caries.

Methods: In this study, Linkage disequilibrium score (LDSC) regression method was used to found the genetic correlation between different sleep traits and DC, while bidirectional Mendelian randomization (MR) methods were used to explore the causal relationship. The main analysis of MR was inverse variance weighted method, and the outcomes were evaluated by odds ratio (OR) and 95% confidence interval (95% CI).

Results: In LDSC regression analysis, genetic correlations were found between chronotype, dozing, insomnia, sleep duration and DC (P = 0.002, P = 0.026, P = 7.233E-09, P = 0.012). However, when utilizing the TSMR method, no discernible casual relationships were found between chronotype, dozing, insomnia, sleep duration and DC (P = 0.832, P = 0.129, P = 0.822, P = 0.644). This result was further substantiated through the utilization of additional validation datasets.

Conclusions: Our study found no causal relationship between sleep traits and DC.

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来源期刊

International Journal of Behavioral Medicine PSYCHOLOGY, CLINICAL-

CiteScore

5.20

自引率

3.70%

发文量

期刊介绍： The International Journal of Behavioral Medicine (IJBM) is the official scientific journal of the International Society for Behavioral Medicine (ISBM). IJBM seeks to present the best theoretically-driven, evidence-based work in the field of behavioral medicine from around the globe. IJBM embraces multiple theoretical perspectives, research methodologies, groups of interest, and levels of analysis. The journal is interested in research across the broad spectrum of behavioral medicine, including health-behavior relationships, the prevention of illness and the promotion of health, the effects of illness on the self and others, the effectiveness of novel interventions, identification of biobehavioral mechanisms, and the influence of social factors on health. We welcome experimental, non-experimental, quantitative, qualitative, and mixed-methods studies as well as implementation and dissemination research, integrative reviews, and meta-analyses.