{"title":"影响范围：在肿瘤中寻找看不见的真菌。","authors":"Ning-Ning Liu","doi":"10.1128/msphere.00988-24","DOIUrl":null,"url":null,"abstract":"<p><p>Ningning Liu works in the field of fungal infection and cancer progression, with a particular focus on the mechanism of host-pathogen interaction. In this mSphere of influence article, he reflects on how papers entitled \"The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL,\" by B. Aykut, S. Pushalkar, R. Chen, Q. Li, et al. (Nature 574:264-267, 2019, https://doi.org/10.1038/s41586-019-1608-2), and \"A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors,\" by A. B. Dohlman, J. Klug, M. Mesko, I. H. Gao, et al. (Cell 185:3807-3822.E12, 2022, https://doi.org/10.1016/j.cell.2022.09.015), emphasized the non-negligible role of fungi in the host and demonstrated a connection between fungi and cancer. These researches arouse his interest in seeking the novel fungal pathogen lurking inside tumors and understanding the unexplored mechanisms behind the severe fungal infections in cancer patients.</p>","PeriodicalId":19052,"journal":{"name":"mSphere","volume":" ","pages":"e0098824"},"PeriodicalIF":3.7000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852992/pdf/","citationCount":"0","resultStr":"{\"title\":\"mSphere of Influence: Seeking the unseen fungi in tumors.\",\"authors\":\"Ning-Ning Liu\",\"doi\":\"10.1128/msphere.00988-24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ningning Liu works in the field of fungal infection and cancer progression, with a particular focus on the mechanism of host-pathogen interaction. In this mSphere of influence article, he reflects on how papers entitled \\\"The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL,\\\" by B. Aykut, S. Pushalkar, R. Chen, Q. Li, et al. (Nature 574:264-267, 2019, https://doi.org/10.1038/s41586-019-1608-2), and \\\"A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors,\\\" by A. B. Dohlman, J. Klug, M. Mesko, I. H. Gao, et al. (Cell 185:3807-3822.E12, 2022, https://doi.org/10.1016/j.cell.2022.09.015), emphasized the non-negligible role of fungi in the host and demonstrated a connection between fungi and cancer. These researches arouse his interest in seeking the novel fungal pathogen lurking inside tumors and understanding the unexplored mechanisms behind the severe fungal infections in cancer patients.</p>\",\"PeriodicalId\":19052,\"journal\":{\"name\":\"mSphere\",\"volume\":\" \",\"pages\":\"e0098824\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-02-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852992/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"mSphere\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1128/msphere.00988-24\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"mSphere","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1128/msphere.00988-24","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
刘宁宁在真菌感染和癌症进展领域工作，主要研究宿主-病原体相互作用的机制。在这篇影响范围的文章中，他反思了题为“真菌菌群通过激活MBL促进胰腺肿瘤发生”的论文，作者是B. Aykut， S. Pushalkar， R. Chen， Q. Li等人（Nature 574:264-267, 2019, https://doi.org/10.1038/s41586-019-1608-2），以及“泛癌症真菌菌群分析揭示了真菌参与胃肠道和肺部肿瘤”，作者是A. B. Dohlman， J. Klug， M. Mesko， I. H. Gao等人（Cell 185:3807-3822）。E12, 2022, https://doi.org/10.1016/j.cell.2022.09.015)，强调了真菌在宿主体内不可忽视的作用，并证明了真菌与癌症之间的联系。这些研究引起了他对寻找潜伏在肿瘤内部的新型真菌病原体和了解癌症患者严重真菌感染背后未被探索的机制的兴趣。
mSphere of Influence: Seeking the unseen fungi in tumors.
Ningning Liu works in the field of fungal infection and cancer progression, with a particular focus on the mechanism of host-pathogen interaction. In this mSphere of influence article, he reflects on how papers entitled "The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL," by B. Aykut, S. Pushalkar, R. Chen, Q. Li, et al. (Nature 574:264-267, 2019, https://doi.org/10.1038/s41586-019-1608-2), and "A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors," by A. B. Dohlman, J. Klug, M. Mesko, I. H. Gao, et al. (Cell 185:3807-3822.E12, 2022, https://doi.org/10.1016/j.cell.2022.09.015), emphasized the non-negligible role of fungi in the host and demonstrated a connection between fungi and cancer. These researches arouse his interest in seeking the novel fungal pathogen lurking inside tumors and understanding the unexplored mechanisms behind the severe fungal infections in cancer patients.
期刊介绍：
mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
