慢性乙型肝炎感染母亲患者报告的结果：横断面分析

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2025-01-25 DOI:10.1016/j.clinre.2025.102537

Shi OuYang , Yueying Deng , Yawen Geng , Xiaoli Yuan , Tingting Peng , Junchao Qiu , Zhirong Xiao , Shengguang Yan , Haitao Deng , Xiaotong Peng , Calvin Q. Pan

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引用次数: 0

摘要

背景与目的：妊娠期间与健康相关的生活质量（HRQoL）在慢性乙型肝炎（CHB）母亲中尚未得到很好的研究。我们的目的是比较怀孕期间CHB母亲与健康母亲的患者报告结局（PROs）。方法：在2023年4月16日至2023年7月31日期间，我们邀请连续的CHB和健康母亲完成自我管理的36项简短表格调查（SF-36）和慢性肝病问卷（CLDQ）进行PRO评估。各组PRO评分两两比较采用卡方检验。结果：257名受试者（CHB：健康对照为100:157），平均（SD）年龄为29.6（3.4）岁，多数在16 ~ 24孕周完成PRO评估。与健康母亲相比，CHB母亲忧虑CLDQ域的pro值显著降低（6.97±0.16 vs 5.83±0.99），p20万IU/mL与pro值显著降低相关。多变量分析发现慢性乙型肝炎感染、严重恶心或呕吐、生活条件差和配偶消极态度是HRQoL损害的独立预测因素。结论：本研究提示妊娠期CHB感染对HRQoL有负面影响，尤其是在担忧和社会功能领域。慢性乙型肝炎感染是PRO损伤的独立预测因子。在处理妊娠期CHB母亲时，应考虑进一步整合对HRQoL损害的监测和干预。

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Patient-reported outcomes in mothers with chronic hepatitis B infection: A cross-sectional analysis

Background & Aims

The health-related quality of life (HRQoL) during pregnancy has not been well-lidated in mothers with chronic hepatitis B (CHB). We aim to compare patient-reported outcomes (PROs) in CHB mothers with those of healthy mothers during pregnancy.

Methods

Between 4/16/2023 and 7/31/2023, we invited consecutive CHB and healthy mothers to complete the self-administered 36-item Short Form Survey (SF-36) and the Chronic Liver Disease Questionnaire (CLDQ) for PRO assessment. Pairwise comparisons of PRO scores between groups were performed using chi-square tests. Covariates for worse PROs were further analyzed by the multiple linear regression model to identify the independent predictors

Results

Among 257 participants (CHB: healthy control was 100:157), the mean (SD) age was 29.6 (3.4), and the majority completed the PRO assessment at the gestational weeks of 16–24. When compared to healthy mothers, CHB mothers had a significant impairment of PROs in the CLDQ domain of worry (6.97±0.16 vs 5.83±0.99, p<0.05) and the SF-36 domain of social functioning (95.33±10.00 vs 91.67±16.37, p<0.05). The subgroup analyses in CHB mothers showed HBV DNA >200,000 IU/mL associated with significantly worse PROs. The multivariate analyses identified CHB infection, severe nausea or vomiting, poor living conditions, and spousal negative attitude as independent predictors of HRQoL impairment.

Conclusion

This study suggests that CHB infection during pregnancy negatively impacted HRQoL, particularly in worry and social functioning domains. CHB infection was an independent predictor for PRO impairments. Further integration of monitoring and intervention on HRQoL impairment should be considered when managing CHB mothers during pregnancy.

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.