[Investigation of the Influence of Image Reconstruction Parameters to Improve the Ability to Depict Internal Tumor Necrosis].

Purpose: There are attempts to assess tumor heterogeneity by texture analysis. However, the ordered subsets-expectation maximization (OSEM) reconstruction method has problems depicting heterogeneities. The aim of this study was to identify image reconstruction parameters that improve the ability to depict internal tumor necrosis using a self-made phantom that simulates internal necrosis.

Methods: Self-made phantoms were prepared using polypropylene cylinders with inner diameters of 18.0 mm and 6.0 mm. The concentration ratios of the simulated tumor : tumor interior were 4 : 0 and 4 : 1. For each reconstruction method, the iteration for OSEM and OSEM+point spread function (PSF) were 1 to 25 and the subset was 12. The β values for block sequential regularized expectation maximization (BSREM) were set between 10 and 400. We evaluated the features of the profile curve, contrast-to-noise ratio, and grey-level co-occurrence matrix (GLCM).

Results: In the phantom study, OSEM and OSEM+PSF showed a better delineation of the differences between the inside and outside of the cylinder as iteration was increased and BSREM showed a better delineation as β was decreased. The highest value for each feature, both 4 : 0 and 4 : 1, was BSREM β 10 for angular second moment (ASM) and inverse differential moment (IDM), OSEM iteration 25 for contrast and entropy.

Conclusion: We have identified image reconstruction parameters that improve the ability to visualize internal tumor necrosis. The parameter was BRSEM β 10.