HFE p.C282Y纯合子平均红细胞体积的相关因素。

EJHaem Pub Date : 2024-12-21 DOI:10.1002/jha2.1063

James C. Barton, J. Clayborn Barton, Ronald T. Acton

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引用次数: 0

摘要

简介：本研究的目的是确定除转铁蛋白饱和度（TS）外的其他因素与HFE p.C282Y （rs1800562）纯合子平均红细胞体积（MCV）和巨细胞增殖（MCV bbb100 fL）之间的关系。方法：我们研究了筛查后具有p.C282Y纯合子的白人参与者，他们没有贫血，没有报告肝硬化或怀孕，也没有使用增加MCV的药物。我们分析了MCV和巨噬细胞增多症与年龄、性别、糖尿病报告、每日饮酒量、第2 /3掌指关节肿胀或压痛、TS和血清铁蛋白（SF）的关系。结果：共有257名参与者（男性110人，女性147人）。男性的中位酒精摄入量、中位TS、中位SF和巨细胞增多症患病率显著高于男性。男性巨细胞增多症的相对危险度为2.81。在男性和女性中，MCV与年龄之间存在显著的Pearson正相关，MCV与饮酒和TS之间存在Spearman正相关。患有第二/第三MCP关节肿胀或压痛的参与者中，MCV和巨噬细胞增多症的平均患病率显著高于未患有第二/第三MCP关节的参与者。结论：HFE p. c282y纯合子的MCV与年龄、每日饮酒量、TS和第2 /3 MCP关节肿胀或压痛呈正相关。

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Factors related to mean corpuscular volume in HFE p.C282Y homozygotes

Introduction

The aim of this study was to define the relationships between factors other than transferrin saturation (TS) to mean corpuscular volume (MCV) and macrocytosis (MCV > 100 fL) in HFE p.C282Y (rs1800562) homozygotes.

Methods

We studied white post-screening participants with p.C282Y homozygosity who did not have anemia, report cirrhosis or pregnancy, or use medications that increase MCV. We analyzed relations of MCV and macrocytosis with age, sex, diabetes reports, daily alcohol consumption, swollen or tender 2nd/3rd metacarpophalangeal (MCP) joints, TS, and serum ferritin (SF).

Results

There were 257 participants (110 men and 147 women). Median alcohol consumption, median TS, median SF, and macrocytosis prevalence were significantly greater in men. Relative risk of macrocytosis in men was 2.81. In men and women, there were significant positive Pearson's correlations of MCV versus age and Spearman's correlations of MCV versus alcohol consumption and TS. Mean MCV and macrocytosis prevalence were significantly greater in participants with than without swollen or tender 2nd/3rd MCP joints. Linear regression on MCV revealed positive associations: age (p < 0.0001), alcohol consumption (p = 0.0007), and TS (p < 0.0001). Logistic regression on macrocytosis revealed an odds ratio for age of 1.04 (95% confidence interval: 1.00, 1.07).

Conclusions

MCV in HFE p.C282Y homozygotes is positively related to age, daily alcohol consumption, TS, and swollen or tender 2nd/3rd MCP joints.

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EJHaem

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