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EJHaem Pub Date : 2024-12-18 DOI:10.1002/jha2.1054

Hitomi Yonesu, Satoru Hamada, Hideki Sakiyama, Shinobu Kiyuna, Tokiko Oshiro, Nobuyuki Hyakuna, Koichi Nakanishi

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引用次数: 0

摘要

简介营养风险指数（NRI）是利用血清白蛋白水平和体重比值计算得出的，是成人造血细胞移植（HCT）的一个已知预后因素。然而，该指数在儿科造血干细胞移植中的作用仍不明确：在一项回顾性研究中，我们考察了82名接受异基因造血干细胞移植的儿科患者移植前NRI对预后的影响：结果：高 NRI 组和低 NRI 组的 2 年非复发死亡率（NRM）分别为 7.94%（95% 置信区间 [CI]，3.05%-19.8%）和 30.8%（95% CI，16.7%-52.2%）（P = 0.0037）：我们发现，小儿 HCT 前营养状况不良会导致预后较差，包括 NRM 增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Association of the nutritional risk index recorded prior to allogeneic hematopoietic cell transplantation with the clinical prognosis in children

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Association of the nutritional risk index recorded prior to allogeneic hematopoietic cell transplantation with the clinical prognosis in children

Introduction

The nutritional risk index (NRI), calculated using serum albumin levels and body weight ratio is a known prognostic factor in adult hematopoietic cell transplantation (HCT). However, its usefulness in pediatric HCT settings remains unclear.

Methods

In a retrospective study, we examined pre-transplant NRI impact on outcomes in 82 pediatric patients undergoing allogeneic HCT.

Results

The 2-year non-relapse mortality (NRM) rate was 7.94% (95% confidence interval [CI], 3.05%–19.8%) and 30.8% (95% CI, 16.7%–52.2%) in the high and low NRI groups, respectively (p = 0.0037).

Conclusion

We found that poor nutritional status prior to pediatric HCT led to a worse prognosis, including increased NRM.

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EJHaem

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