Unmasking the Culprit: Reframing Pain in Research and Management of Patellofemoral Pain.

SYNOPSIS: This editorial draws an analogy between the literary genre of the 'whodunit' and the complexities of patellofemoral pain (PFP). Traditionally, PFP management has centered on biomechanical factors such as hip muscle weakness, foot pronation, and patellar tracking issues. However, long-term outcomes often remain unsatisfactory, highlighting the need for alternative strategies. The editorial underscores the significance of addressing the predominant pain pathway rather than relying solely on biomechanical assessments. It calls for future research to integrate pain characteristics into clinical practice to enhance outcomes.Just as a mystery is difficult to solve by focusing on 1 suspect, PFP is a multifaceted condition arising from a variety of contributing factors, including pain pathways that are often overshadowed by biomechanics. By thoroughly examining the dimensions and characteristics of pain, clinicians and researchers can refine clinical strategies and advance patient care, and ensure a tailored approach to managing this challenging condition. J Orthop Sports Phys Ther 2025;55(2):1-3. Epub 15 January 2025. doi:10.2519/jospt.2025.12883.