自然杀伤细胞在帕金森病中的双刃剑作用。

IF 2.9 4区 医学 Q2 CELL BIOLOGY
Delbar Daneshjou , Seyed Masood Nabavi , Parisa Shams , Pooya Faranoush , Mehri Salari , Marzieh Ebrahimi
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引用次数: 0

摘要

神经系统疾病是世界范围内致残的主要原因,帕金森病(PD)在全球范围内成为一种快速增长的神经系统疾病。虽然现有的治疗方法可以缓解症状并维持患者的生活质量,但PD仍然无法治愈。根据最近的一些研究,自然杀伤(NK)细胞可能在清除α -突触核蛋白聚集体中发挥作用,α -突触核蛋白聚集体是导致帕金森病神经元变性的路易小体的主要成分。NK细胞也可能通过调节炎症和抗原呈递细胞功能对这种情况产生不利影响。修饰来自不同来源的NK细胞,如脐带血,为PD患者的免疫治疗提供了一条有希望的途径,特别是在疾病的早期阶段。因此,需要进一步的研究来阐明NK细胞在帕金森病患者中的作用机制,并评估其作为潜在生物标志物或治疗靶点的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The double-edged sword role of natural Killer cells in Parkinson's disease
Neurological disorders are the leading cause of disability worldwide, with Parkinson's disease (PD) emerging as a rapidly growing neurological condition on a global scale. Although treatments exist to alleviate symptoms and maintain patients' quality of life, PD remains incurable. According to some recent studies, natural killer (NK) cells may play a role in clearing alpha-synuclein aggregates, which are the main component of Lewy bodies that cause neuronal degeneration in Parkinson's disease. NK cells may also have an adverse impact on this condition by modulating inflammation and antigen-presenting cell function. Modifying NK cells derived from diverse sources, such as umbilical cord blood, presents a promising avenue for immunotherapy in PD patients, particularly during the early stages of the condition. Consequently, further research is essential to elucidate the mechanisms by which NK cells operate in Parkinson's patients and to assess their viability as potential biomarkers or therapeutic targets.
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来源期刊
Cellular immunology
Cellular immunology 生物-免疫学
CiteScore
8.20
自引率
2.30%
发文量
102
审稿时长
30 days
期刊介绍: Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.
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