社会群体的规模会改变社会行为和多巴胺能系统和血清素系统。

IF 1.7 4区 医学 Q4 NEUROSCIENCES
Social Neuroscience Pub Date : 2025-02-01 Epub Date: 2025-01-25 DOI:10.1080/17470919.2025.2454257
Ye-Jin Kim, Young-A Lee
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引用次数: 0

摘要

社会行为受社会结构类型的影响,但神经功能如何随社会类型而变化尚不清楚。我们研究了基于多巴胺(DA)和血清素(5-HT)系统的社会群体规模是否影响社会行为。四周大的雄性小鼠被安置在不同的社会群体中:每笼一只、两只、四只和八只小鼠(分别为1mpc、2mpc、4mpc、8mpc)。4周后,分别进行社会偏好、社会互动和强迫游泳测试以测试社交能力和焦虑,随后分析DA和5-羟色胺及其代谢物(3,4-二羟基苯基乙酸[DOPAC]、3-甲氧基酪胺[3- mt]、去甲肾上腺素和5-羟基吲哚乙酸[5-HIAA])。社交互动和焦虑行为随着社交群体规模的增加而减少。DA、3-MT和5-HT水平随着社会群体规模的增加而降低,而包括背纹状体在内的扩展中皮质边缘系统的DOPAC和5-HIAA水平则升高。此外,社会群体规模的增加导致DOPAC/DA和5-HIAA/5-HT比值的增加,同时伴有扩展中皮质边缘系统内3-MT/DA比值的降低。线性回归分析还发现,社会群体规模对DA和5-HT周转有影响。这些结果表明,社会群体的大小可能会影响行为和单胺水平,从而可能导致与DA和5- ht相关的精神疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Social group size alters social behavior and dopaminergic and serotonergic systems.

Social behavior is affected by social structure type, but how neural function changes with social type remains unclear. We investigated whether social group size affects social behaviors based on dopamine (DA) and serotonin (5-HT) systems. Four-week-old male mice were housed under different social group sizes: one, two, four, and eight mice per cage (1mpc, 2mpc, 4mpc, 8mpc, respectively). After 4 weeks, social preference, social interaction, and forced swim tests were performed to test sociability and anxiety, respectively, followed by analysis of DA and 5-HT and their metabolites (3,4-dihydroxyphenylacetic acid [DOPAC], 3-methoxytyramine [3-MT], norepinephrine, and 5-hydroxyindoleacetic acid [5-HIAA]). Social interactions and anxious behavior decreased with increased social group size. DA, 3-MT, and 5-HT levels decreased with increasing social group size, whereas DOPAC and 5-HIAA levels increased in the extended mesocorticolimbic system, including the dorsal striatum. Moreover, the increased social group size resulted in increased DOPAC/DA and 5-HIAA/5-HT ratios, accompanied by a decrease in the 3-MT/DA ratio within the extended mesocorticolimbic system. Linear regression analysis also revealed that social group size affects DA and 5-HT turnover. These suggest that social group size may influence behavior and monoamine levels, potentially contributing to DA- and 5-HT-related psychiatric disorders.

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来源期刊
Social Neuroscience
Social Neuroscience 医学-神经科学
CiteScore
3.40
自引率
5.00%
发文量
36
审稿时长
6-12 weeks
期刊介绍: Social Neuroscience features original empirical Research Papers as well as targeted Reviews, Commentaries and Fast Track Brief Reports that examine how the brain mediates social behavior, social cognition, social interactions and relationships, group social dynamics, and related topics that deal with social/interpersonal psychology and neurobiology. Multi-paper symposia and special topic issues are organized and presented regularly as well. The goal of Social Neuroscience is to provide a place to publish empirical articles that intend to further our understanding of the neural mechanisms contributing to the development and maintenance of social behaviors, or to understanding how these mechanisms are disrupted in clinical disorders.
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