丁苯酞预防缺血性脑卒中幸存者认知能力下降的疗效:一项为期12个月的前瞻性随访研究

IF 2.6 1区 医学
Qingqing Han, Xiyu Zhao, Yingzhe Shao, Fengtao Tan, Haotian Wen, Di Wang, Xiao Li, Yunfan Wang, Jun Tu, Lifeng Wang, Xianjia Ning, Jinghua Wang, Yan Li
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引用次数: 0

摘要

背景:认知能力下降是中风幸存者的一个重要问题,影响他们的生活质量,增加他们对医疗保健系统的负担。dl -3-正丁苯酞(丁苯酞)已显示出短期治疗各种认知障碍的疗效。本研究评估了丁苯酞在缺血性脑卒中患者12个月期间预防认知能力下降的疗效。方法:这项前瞻性随访研究纳入新诊断为缺血性卒中的患者,在卒中发作后1 - 6个月,非急性期。患者被分为丁苯酞组和对照组。认知功能在基线和12个月随访时采用简易精神状态检查(MMSE)进行评估。统计分析包括t检验、χ2检验和多元回归分析。结果:丁苯酞与MMSE d值呈负相关(β=-0.122;95% CI -1.932 ~ -0.298;p=0.003)和MMSE d值百分比(β=-0.117;95% CI为-0.057 ~ -0.011;p = 0.004)。多变量分析表明丁苯酞治疗与取向和语言评分的变化呈负相关。此外,丁苯酞组认知能力下降的发生率显著降低(OR, 0.612;P =0.020)。年龄≥60岁和受教育程度较低是认知评分较低和认知能力下降的危险因素。结论:本研究表明丁苯酞可有效预防缺血性脑卒中患者认知能力下降。这些发现对临床实践具有重要意义,表明丁苯酞可纳入卒中后标准护理方案,以改善患者预后并减轻医疗负担。建议在不同人群中进行更多的多中心双盲试验来证实这些结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of butylphthalide in preventing cognitive decline in ischaemic stroke survivors: a 12-month prospective following-up study.

Background: Cognitive decline is a significant concern for stroke survivors, affecting their quality of life and increasing their burden on the healthcare system. DL-3-n-butylphthalide (butylphthalide) has shown efficacy in the short-term treatment of various cognitive impairments. This study evaluated the efficacy of butylphthalide in preventing cognitive decline over a 12-month period in patients with ischaemic stroke.

Methods: This prospective following-up study involved patients newly diagnosed with ischaemic stroke between 1 month and 6 months after stroke onset and not in the acute phase. Patients were assigned to either the butylphthalide or control group. Cognitive function was assessed using the mini-mental state examination (MMSE) at baseline and at the 12-month follow-up. Statistical analyses included t-tests, χ2 tests and multivariate regression analyses.

Results: Butylphthalide was negatively associated with the MMSE D-value (β=-0.122; 95% CI -1.932 to -0.298; p=0.003) and the MMSE D-value percentage (β=-0.117; 95% CI -0.057 to -0.011; p=0.004). A multivariate analysis indicated that butylphthalide treatment was negatively associated with both changes in orientation and language score. Additionally, the incidence of cognitive decline was significantly lower in the butylphthalide group (OR, 0.612; p=0.020) than the control group. An age of ≥60 years and lower educational level were identified as risk factors for lower cognitive score and cognitive decline.

Conclusion: This study demonstrated that butylphthalide is effective in preventing cognitive decline in patients with ischaemic stroke. These findings have significant implications for clinical practice, suggesting that butylphthalide could be incorporated into standard post-stroke care regimens to improve patient outcomes and reduce the healthcare burden. Additional multicentre double-blind trials are recommended to confirm these results in diverse populations.

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来源期刊
Journal of Investigative Medicine
Journal of Investigative Medicine MEDICINE, GENERAL & INTERNALMEDICINE, RESE-MEDICINE, RESEARCH & EXPERIMENTAL
自引率
0.00%
发文量
111
期刊介绍: Journal of Investigative Medicine (JIM) is the official publication of the American Federation for Medical Research. The journal is peer-reviewed and publishes high-quality original articles and reviews in the areas of basic, clinical, and translational medical research. JIM publishes on all topics and specialty areas that are critical to the conduct of the entire spectrum of biomedical research: from the translation of clinical observations at the bedside, to basic and animal research to clinical research and the implementation of innovative medical care.
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