1990年至2021年全球、地区和国家神经母细胞瘤和其他周围神经系统肿瘤的负担及2035年预测：基于GBD 2021可视化流行病学特征

IF 4.8 2区医学 Q1 Biochemistry, Genetics and Molecular Biology

Neoplasia Pub Date : 2025-02-01 DOI:10.1016/j.neo.2025.101122

Chaoyan Yue , Qi Zhang , Fenyong Sun , Qiuhui Pan

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引用次数: 0

摘要

背景：神经母细胞瘤（Neuroblastoma， NB）是儿童最常见的颅外恶性实体瘤，占儿童癌症相关死亡的15%。我们分析了1990 - 2021年全球疾病负担（GBD）数据库中神经母细胞瘤和其他周围神经系统肿瘤患者的流行病学统计指标，旨在为公共卫生干预和临床实践提供有价值的见解。方法：基于GBD 2021数据库，按社会人口发展指数（SDI）和地理区域分层，分析1990 - 2021年神经母细胞瘤和其他周围神经系统肿瘤的发病率、死亡率、患病率和伤残调整生命年（DALYs）。进行了跨国不平等分析，以量化各国与sdi相关的疾病负担不平等。采用年均百分比变化（AAPC）和年龄-时期-队列（APC）模型评价疾病负担趋势，采用贝叶斯年龄-时期-队列（BAPC）模型预测到2035年全球疾病负担。研究结果：本研究首次报道了GBD 2021数据库中神经母细胞瘤和其他周围神经系统肿瘤的疾病负担。在全球范围内，从1990年到2021年，神经母细胞瘤的发病率和死亡率逐年上升，特别是在SDI较低的地区，如南亚和撒哈拉以南非洲，疾病负担显著增加。SDI高的地区，如北美和西欧，由于医疗保健水平提高和早期诊断，疾病负担有所减轻。年龄分布表明，受影响的主要是5岁以下儿童，特别是中低收入地区。此外，男性的发病率略高于女性。BAPC模型预测，神经母细胞瘤的全球发病率、死亡率和DALYs将继续增加，直到2035年。解释：神经母细胞瘤和其他周围神经系统肿瘤在世界范围内存在显著的区域和人群差异，在医疗资源有限的低SDI地区，疾病负担特别高。这一趋势突出了全球公共卫生干预和资源分配的迫切需要，特别是在低收入国家。未来的研究应侧重于改善早期诊断、风险分层和靶向治疗，以减轻全球疾病负担，改善患者预后。基金资助：国家自然科学基金（No. 82293662, No. 82172357, No. 81930066），上海市科技创新行动计划重点项目（No. 22JC1402304），上海市卫生局科研基金（No. 2019cxjq03）。

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Global, regional and national burden of neuroblastoma and other peripheral nervous system tumors, 1990 to 2021 and predictions to 2035: visualizing epidemiological characteristics based on GBD 2021

Background

Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children, accounting for >15 % of cancer-related deaths in children. We analyzed the epidemiological statistical indicators of neuroblastoma and other peripheral nervous system tumors patients from 1990 to 2021 in Global Burden of Disease (GBD) 2021 database, aiming to provide valuable insights for public health interventions and clinical practices.

Methods

Based on the GBD 2021 database, this study analyzed the incidence, mortality, prevalence, and Disability-Adjusted Life-Years (DALYs) of neuroblastoma and other peripheral nervous system tumors from 1990 to 2021, stratified by sociodemographic development index (SDI) and geographic regions. Cross-country inequalities analysis was conducted to quantify the SDI-related inequality of disease burden across countries. In addition, the average annual percentage change (AAPC) and Age-Period-Cohort (APC) model were used to evaluate the trend of disease burden, while the global burden of disease to 2035 was predicted by Bayesian Age-Period-Cohort (BAPC) model.

Findings

This study reported the disease burden of neuroblastoma and other peripheral nervous system tumors in GBD 2021 database for the first time. Globally, the incidence and mortality of neuroblastoma have increased year by year from 1990 to 2021, especially in regions with low SDI, such as South Asia and sub-Saharan Africa, where the burden of disease has increased significantly. Regions with high SDI, such as North America and Western Europe, have seen a reduction in disease burden due to higher levels of medical care and earlier diagnosis. The age distribution shows that children under 5 years of age are mainly affected, especially in low- and middle-income areas. In addition, the incidence is slightly higher in men than in women. The BAPC model predicts that the global incidence, mortality, and DALYs of neuroblastoma will continue to increase until 2035.

Interpretation

Significant regional and population variation in neuroblastoma and other peripheral nervous system tumors worldwide, with a particularly high disease burden in low SDI areas with limited medical resources. This trend highlights the urgent need for global public health interventions and resource allocation, particularly in low-income countries. Future research should focus on improving early diagnosis, risk stratification and target therapy in order to reduce the global burden of disease and improve patients’ prognosis.

Funding

This study was supported by National Natural Science Foundation of China (No. 82293662, No 82172357 and No 81930066), Key project of Shanghai "Science and Technology Innovation Action Plan (22JC1402304) and Research fund of Shanghai Municipal Health Bureau (No. 2019cxjq03).

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来源期刊

Neoplasia 医学-肿瘤学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

26 days

期刊介绍： Neoplasia publishes the results of novel investigations in all areas of oncology research. The title Neoplasia was chosen to convey the journal’s breadth, which encompasses the traditional disciplines of cancer research as well as emerging fields and interdisciplinary investigations. Neoplasia is interested in studies describing new molecular and genetic findings relating to the neoplastic phenotype and in laboratory and clinical studies demonstrating creative applications of advances in the basic sciences to risk assessment, prognostic indications, detection, diagnosis, and treatment. In addition to regular Research Reports, Neoplasia also publishes Reviews and Meeting Reports. Neoplasia is committed to ensuring a thorough, fair, and rapid review and publication schedule to further its mission of serving both the scientific and clinical communities by disseminating important data and ideas in cancer research.