金属纳米粒子在淋巴瘤动物模型研究中的生物分布。

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology
Methods in cell biology Pub Date : 2025-01-01 Epub Date: 2024-08-23 DOI:10.1016/bs.mcb.2024.07.004
Barbara Chalhoub, Víctor Franco Puntes, Laura Mondragón
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引用次数: 0

摘要

T细胞淋巴瘤是一组复杂的疾病,具有异质性的分子特征和临床症状,无论选择何种治疗策略,结果都令人沮丧。为了提高患者的生存机会,已经测试了治疗组合(化疗、放疗、免疫治疗、基因治疗和热疗法)的协同效应,当治疗效果叠加而副作用分散时,可能会显著改善结果并减少每种单一模式治疗的副作用。在此背景下,纳米级药物递送剂已被开发和利用,以增强药物在治疗几种疾病中的释放,在药物灵活性、选择性、剂量减少和不良反应最小化方面显示出潜在的益处。无机材料(即金属纳米颗粒)可以用作成像和放疗剂,这表明基于纳米颗粒的治疗方法可以结合起来,作为靶向肿瘤的“精准药物”,同时保持健康组织的完整。因此,纳米颗粒(NPs)似乎是多模式治疗的理想平台,在寻找T细胞淋巴瘤的有效联合治疗中,它是一种更有前途的策略。在我们的实验室中,我们的目标是验证这些治疗策略,使金属NPs能够同时提供诊断和治疗效果。由于实验室开发的体内T细胞淋巴瘤动物模型的可用性,合成的NPs将有可能得到验证。在这里,我们描述了实体肿瘤的给药和生物分布研究的基本方案,这可能对未来治疗的发展和随访有重要的帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metallic nanoparticles biodistribution for the study of lymphoma in animal models.

T cell lymphoma constitutes a complex group of diseases, characterized by heterogeneous molecular features and clinical symptoms, and a dismal outcome no matter the therapeutic strategy chosen. In an attempt to improve patients' survival chances, treatment combinations (chemotherapy, radiotherapy, immunotherapy, gene therapy and thermotherapy) have been tested for their synergistic effects that may dramatically improve outcomes and reduce the side effects of each single modality treatment when therapeutic effects add up while side effects are distributed. In this context, nanoscale drug delivery agents have been developed and exploited to enhance the release of drugs in the treatment of several diseases, showing potential benefits in terms of pharmaceutical flexibility, selectivity, dose reduction and minimization of adverse effects. Inorganic materials (i.e., metal nanoparticles) can be used as imaging and radiotherapy agents demonstrating that nanoparticle-based therapies can combine and act as "precision medicine" for targeting tumors while leaving healthy tissue intact. Therefore, nanoparticles (NPs) appear as ideal platforms for multimodal therapy constituting a more than promising strategy in the search of effective combined treatments for T cell lymphoma. In our laboratory, we aim at validating these therapeutic strategies making use of metal NPs able to provide a diagnostic and therapeutic effect at the same time. Validation of the synthesized NPs will be possible thanks to the availability of an in vivo T cell lymphoma animal model also developed in the lab. Here, we describe basic protocols for the administration and biodistribution studies in solid tumors which could be of significant help for future therapies development and follow-up.

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来源期刊
Methods in cell biology
Methods in cell biology 生物-细胞生物学
CiteScore
3.10
自引率
0.00%
发文量
125
审稿时长
3 months
期刊介绍: For over fifty years, Methods in Cell Biology has helped researchers answer the question "What method should I use to study this cell biology problem?" Edited by leaders in the field, each thematic volume provides proven, state-of-art techniques, along with relevant historical background and theory, to aid researchers in efficient design and effective implementation of experimental methodologies. Over its many years of publication, Methods in Cell Biology has built up a deep library of biological methods to study model developmental organisms, organelles and cell systems, as well as comprehensive coverage of microscopy and other analytical approaches.
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