n -酰基腙类化合物抗结直肠癌的潜力综述

IF 2.6 4区 医学 Q3 CHEMISTRY, MEDICINAL
Darna Mounika, Sai Satya Sri Pulla, Swapnil Anil Sule, Vidya Jyothi Alli, Surender Singh Jadav
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引用次数: 0

摘要

结直肠癌(Colorectal cancer, CRC)是一种发病率和死亡率高且呈上升趋势的恶性胃肠道疾病。治疗结直肠癌的标准疗法是手术和化疗。尽管在开发有效的治疗方法方面付出了巨大的努力,但由于其复发和复发,进展有限。转移性结直肠癌预后复杂。这种情况可以通过一种新的方法来避免,即靶向治疗,通过阻断重要途径和作用于免疫检查点来提高CRC患者的生存率。含有n -酰基腙(NAH)的药物目前被用于治疗感染性疾病和疾病。NAH与多种杂环化合物结合,天然产物分离物被认为是尚未开发的有趣的CRC抑制剂。本文综述了现有的具有酰基腙、肼、肼基团的结直肠癌靶向化合物,以及它们对不同结直肠癌细胞系的潜在机制,并讨论了它们的局限性和未来趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potentials of N-Acyl hydrazones Against Colorectal Cancer: A Mini Review.

Colorectal cancer (CRC) is a malignant gastrointestinal tract disorder with high occurrence and mortality index and showing an upsurge. Standard therapies for treating CRC are surgery and chemotherapy. Despite great effort in developing effective treatments, the progress is limited due to its relapse and recurrence. Prognosis of metastatic CRC is always complicated. This condition can be evaded by a novel approach i.e., targeted therapy which increases the survival rate in CRC patients by blocking important pathways and acting on immune checkpoints. Drugs with N-acyl hydrazones (NAH) are currently being employed treatment of infectious diseases and disorders. NAH in combination with diverse heterocycles, natural product isolates are identified as interesting CRC inhibitors under-explored. This review provides an overview of the existing CRC targeted compounds having acyl hydrazones, hydrazine, hydrazides moieties, and their underlying mechanisms towards different CRC cell lines, together with a discussion of their limitations and future trends.

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来源期刊
Anti-cancer agents in medicinal chemistry
Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL
CiteScore
5.10
自引率
3.60%
发文量
323
审稿时长
4-8 weeks
期刊介绍: Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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