四乙烷试剂使能酯合成1,4-二酮

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-25 DOI:10.1021/acs.orglett.4c04690

Miaomiao Wu, Tongchang Fang, Liangxuan Xu, Qingfeng Xu, Jianmei Lu, Chao Liu

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引用次数: 0

摘要

建立了1,4-二酮的模块化合成方法。以廉价的羧酸酯为羰基源，四硼乙烷（TBE）为亲核试剂，建立了一锅法构建两个C-C键的策略。值得注意的是，该反应在没有过渡金属参与的情况下进行，并表现出优异的官能团相容性。采用不同的亲电试剂制备了不同的α-取代1,4-二酮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of 1,4-Diketones from Esters Enabled by a Tetraborylethane Reagent

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Synthesis of 1,4-Diketones from Esters Enabled by a Tetraborylethane Reagent

A modular synthesis method for 1,4-diketones has been developed. Utilizing inexpensive carboxylic acid esters as carbonyl sources and tetraborylethane (TBE) as a nucleophilic reagent, a one-pot strategy for constructing two C–C bonds was established. Notably, this reaction proceeds without the involvement of transition metals and exhibits excellent functional group compatibility. A diverse array of α-substituted 1,4-diketones were synthesized using various electrophiles for capture.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.