Justyna Moppert, Krzysztof Domagalski, Małgorzata Pawłowska
{"title":"评估ABCB11基因单核苷酸多态性作为eb病毒感染儿童肝脏并发症生物标志物的意义","authors":"Justyna Moppert, Krzysztof Domagalski, Małgorzata Pawłowska","doi":"10.5114/ceh.2024.140450","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim of the study: </strong>To evaluate single nucleotide polymorphisms of the adenosine triphosphate (ATP) binding cassette subfamily B member 11 (<i>ABCB11</i>) gene, rs11568364 and rs2287622, as potential predictors of hepatologic complications during Epstein-Barr virus (EBV) infection among children.</p><p><strong>Material and methods: </strong>The study group consisted of 54 children aged 1 to 18 years hospitalised from 01.12.2018 to 31.12.2020 in the Department of Paediatrics, Infectious Diseases and Hepatology with hepatological complications in the course of serologically and molecularly confirmed EBV infection. Real-time PCR using TaqMan probes was used to determine single-nucleotide variability in the <i>ABCB11</i> gene.</p><p><strong>Results: </strong>It was found that the presence of the T allele for the rs2287622 marker increases the probability of hepatitis three times and the possibility of hepatitis with cholestasis almost four times in EBV-infected patients.</p><p><strong>Conclusions: </strong>The rs2287622 polymorphism of the <i>ABCB11</i> gene appears to have an impact on the occurrence of hepatological complications in the course of EBV infection in children.</p>","PeriodicalId":10281,"journal":{"name":"Clinical and Experimental Hepatology","volume":"10 2","pages":"104-110"},"PeriodicalIF":1.5000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748231/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the significance of single nucleotide polymorphisms of the <i>ABCB11</i> gene as biomarkers of hepatological complications in Epstein-Barr virus infection in children.\",\"authors\":\"Justyna Moppert, Krzysztof Domagalski, Małgorzata Pawłowska\",\"doi\":\"10.5114/ceh.2024.140450\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim of the study: </strong>To evaluate single nucleotide polymorphisms of the adenosine triphosphate (ATP) binding cassette subfamily B member 11 (<i>ABCB11</i>) gene, rs11568364 and rs2287622, as potential predictors of hepatologic complications during Epstein-Barr virus (EBV) infection among children.</p><p><strong>Material and methods: </strong>The study group consisted of 54 children aged 1 to 18 years hospitalised from 01.12.2018 to 31.12.2020 in the Department of Paediatrics, Infectious Diseases and Hepatology with hepatological complications in the course of serologically and molecularly confirmed EBV infection. Real-time PCR using TaqMan probes was used to determine single-nucleotide variability in the <i>ABCB11</i> gene.</p><p><strong>Results: </strong>It was found that the presence of the T allele for the rs2287622 marker increases the probability of hepatitis three times and the possibility of hepatitis with cholestasis almost four times in EBV-infected patients.</p><p><strong>Conclusions: </strong>The rs2287622 polymorphism of the <i>ABCB11</i> gene appears to have an impact on the occurrence of hepatological complications in the course of EBV infection in children.</p>\",\"PeriodicalId\":10281,\"journal\":{\"name\":\"Clinical and Experimental Hepatology\",\"volume\":\"10 2\",\"pages\":\"104-110\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748231/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Hepatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/ceh.2024.140450\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/ceh.2024.140450","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Evaluation of the significance of single nucleotide polymorphisms of the ABCB11 gene as biomarkers of hepatological complications in Epstein-Barr virus infection in children.
Aim of the study: To evaluate single nucleotide polymorphisms of the adenosine triphosphate (ATP) binding cassette subfamily B member 11 (ABCB11) gene, rs11568364 and rs2287622, as potential predictors of hepatologic complications during Epstein-Barr virus (EBV) infection among children.
Material and methods: The study group consisted of 54 children aged 1 to 18 years hospitalised from 01.12.2018 to 31.12.2020 in the Department of Paediatrics, Infectious Diseases and Hepatology with hepatological complications in the course of serologically and molecularly confirmed EBV infection. Real-time PCR using TaqMan probes was used to determine single-nucleotide variability in the ABCB11 gene.
Results: It was found that the presence of the T allele for the rs2287622 marker increases the probability of hepatitis three times and the possibility of hepatitis with cholestasis almost four times in EBV-infected patients.
Conclusions: The rs2287622 polymorphism of the ABCB11 gene appears to have an impact on the occurrence of hepatological complications in the course of EBV infection in children.
期刊介绍：
Clinical and Experimental Hepatology – quarterly of the Polish Association for Study of Liver – is a scientific and educational, peer-reviewed journal publishing original and review papers describing clinical and basic investigations in the field of hepatology.
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