实施子宫内膜癌常规错配修复（MMR）免疫组化（IHC）检测和后续患者管理的建议。

IF 1.3 Q4 HEALTH CARE SCIENCES & SERVICES

BMJ Open Quality Pub Date : 2025-01-21 DOI:10.1136/bmjoq-2024-003014

Mohamed Shawky, Maria Murrey, Jo Morrison

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引用次数: 0

摘要

Lynch综合征与癌症风险增加有关，包括子宫内膜癌。我们审核了引入护士主导的林奇综合征检测和管理途径。2022年1月至2023年12月期间，萨默塞特NHS基金会信托基金对所有191名诊断为子宫内膜癌的患者进行了错配修复（MMR）蛋白免疫组织化学检测；所有13名符合条件的人都接受了生殖系检测。7例患者被诊断为Lynch综合征；所有患者都接受了肠道筛查和幽门螺杆菌检测。3/7的患者缺少预防性阿司匹林推荐信息。我们建立了一个有效的，护士主导的林奇综合征检测途径，符合国家指南。

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Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management.

Lynch syndrome is associated with an increased risk of cancer, including endometrial cancer. We audited the introduction of a nurse-led testing and management pathway for Lynch syndrome. All 191 patients diagnosed with endometrial cancer at Somerset NHS Foundation Trust between January 2022 and December 2023 were tested for mis-match repair (MMR) protein immunohistochemistry; germline testing was offered to all 13 who were eligible. Seven patients were diagnosed with Lynch syndrome; all were referred for bowel screening and Helicobacter pylori testing. Information about prophylactic aspirin recommendations was missing for 3/7 patients. We established an effective, nurse-led Lynch syndrome testing pathway, in line with national guidelines.

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