核足小体调节Tau和阿尔茨海默病的细胞迁移。

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

Advances in protein chemistry and structural biology Pub Date : 2025-01-01 Epub Date: 2024-10-02 DOI:10.1016/bs.apcsb.2024.09.009

Tazeen Qureshi, Madhura Chandrashekar, Vaishnavi Ananthanarayana, Murugappan Kumarappan, Nagaraj Rangappa, Gowshika Velmurugan, Subashchandrabose Chinnathambi

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引用次数: 0

摘要

在建立神经保护机制方面，神经元细胞骨架仍然是一个探索较少的研究领域。人们研究了HDAC6与许多神经退行性疾病，特别是AD的关系。它表现出与各种细胞骨架蛋白相互作用并促进细胞迁移的能力。足小体是肌动蛋白的微结构，帮助细胞在细胞外环境中迁移。这篇综述的目的是把重点放在研究足小体参与阿尔茨海默病的意义。我们认为组蛋白去乙酰化酶6在AD中起着至关重要的作用，通过其与细胞中各种信号过程的相互作用，最重要的是在足质体内的细胞骨架重塑机制。

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Nuclear podosomes regulates cellular migration in Tau and Alzheimer's disease.

The neuronal cytoskeleton has remained a less explored area of research in establishing neuroprotection. HDAC6 has been studied with respect to many neurodegenerative diseases, especially AD. It exhibits the ability to interact with various cytoskeletal proteins and to promote migration in cells. Podosomes are actin microstructures that help cells to migrate in the extracellular environment. The aim of this review is to bring into focus the significance of studies on the involvement of podosomes in Alzheimer's disease. We have suggested that Histone Deacetylase 6 plays a vital role in AD, through its interactions with the various signalling processes in the cell, most importantly the cytoskeletal remodelling machinery within the podosomes.

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来源期刊

Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

7.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.