Junjun Ge, Tengyue Yin, Haoyang Zhang, Yue Cao, Juan Liu, Jun-Jie Zhu, Yang Zhou and Yuanyuan Wang
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Photo-crosslinking of doped magic-sized nanoclusters for the construction of enhanced electrochemiluminescence biosensors†
Semiconductor magic-sized nanoclusters (MSCs) possess atomic-level compositional precision and ultrasmall dimensions, allowing accurate modulation of electrochemiluminescence (ECL) properties, essential for advanced bioanalytical applications. However, low intrinsic ECL intensity and poor stability in bipolar electrode (BPE)-ECL systems hinder their broader use. In this work, we addressed these limitations through doping and direct optical crosslinking strategies, achieving a 24-fold boost in the ECL signal and a fivefold stability increase for doped (CdS)34:Ag MSCs compared with original (CdS)34 MSCs. The resulting BPE-ECL biosensing platform was used for the sensitive detection of glucose with a linear detection range of 10 μM to 1 mM and a detection limit of 3.64 μM. This approach provides a robust strategy to enhance MSC-based ECL biosensing, paving the way for ultrasensitive, stable biosensors for clinical diagnostics and bioanalysis.
期刊介绍：
Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.
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