果蝇端粒蛋白Verrocchio是STN1的同源物。

IF 1.3 4区生物学 Q4 GENETICS & HEREDITY

Genetica Pub Date : 2025-01-22 DOI:10.1007/s10709-025-00226-7

Ion Udroiu, Antonella Sgura

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引用次数: 0

摘要

在大多数真核生物中，端粒受到CST复合物的保护，CST复合物由CTC1、STN1和TEN1组成。相反，在果蝇中，存在另一个复合体，由莫迪利亚尼、茶和韦罗基奥组成。我们在节肢动物中进行了STN1同源物的搜索，以验证Verrocchio是否可以被认为是这样的。我们发现节肢动物的STN1比其他后生动物短，与Verrocchio具有相同的结构。尽管人类和果蝇之间的序列差异很大，但我们发现Verrocchio是STN1的同源基因。

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Drosophila telomeric protein Verrocchio is an ortholog of STN1.

In most Eukaryota, telomeres are protected by the CST complex, composed of CTC1, STN1 and TEN1. In Drosophila, instead, another complex is present, composed of Modigliani, Tea and Verrocchio. We performed a search for STN1 orthologs in Arthropoda, in order to verify if Verrocchio can be considered as such. We found that STN1 in Arthropoda is shorter than in other Metazoa and shares the same architecture with Verrocchio. Despite high sequence divergence between human and Drosophila, we have discovered that Verrocchio is an ortholog of STN1.

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来源期刊

Genetica 生物-遗传学

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Genetica publishes papers dealing with genetics, genomics, and evolution. Our journal covers novel advances in the fields of genomics, conservation genetics, genotype-phenotype interactions, evo-devo, population and quantitative genetics, and biodiversity. Genetica publishes original research articles addressing novel conceptual, experimental, and theoretical issues in these areas, whatever the taxon considered. Biomedical papers and papers on breeding animal and plant genetics are not within the scope of Genetica, unless framed in an evolutionary context. Recent advances in genetics, genomics and evolution are also published in thematic issues and synthesis papers published by experts in the field.