Tetiana Y Bowley, Mireya C Ortiz, Irina V Lagutina, Mara P Steinkamp, Bridget N Fahy, Bernard Tawfik, Moises Harari-Turquie, Dario Marchetti
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A Melanoma Brain Metastasis CTC Signature and CTC:B-cell Clusters Associate with Secondary Liver Metastasis: A Melanoma Brain-Liver Metastasis Axis.
Significance: This study provides important insights into the relevance of prometastatic CTC:B-cell clusters in melanoma progression, extends the importance of the CTC RPL/RPS gene signature beyond primary metastasis/melanoma brain metastasis driving targeted organ specificity for liver metastasis ("metastasis of metastasis"), and identifies new targets for clinical melanoma metastasis therapies.
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