对于房颤，doac在肾功能降低患者中优于华法林。

IF 2.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of the American Board of Family Medicine Pub Date : 2025-01-17 DOI:10.3122/jabfm.2024.240155R0

Robert A Powell, Jessica S Coulter, Ariel L Hoffman

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引用次数: 0

摘要

与华法林相比，在标准剂量下，直接口服抗凝剂（DOACs）与系统性栓塞和颅内出血（ICH）的风险降低相关，在较低的肌酐清除率（crcl降至25 mL/min）下有更大的获益。与标准剂量DOACs和华法林相比，低剂量DOACs与总死亡率增加相关，但脑出血和出血发生率没有显著降低，所有CrCl均降至25 mL/min 1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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For Atrial Fibrillation, DOACs Outperform Warfarin in Patients with Reduced Kidney Function.

At standard doses, direct oral anticoagulants (DOACs) were associated with a reduced risk of systemic embolism and intracranial hemorrhage (ICH) when compared with warfarin, with a greater derived benefit at lower creatinine clearance (CrCl-down to 25 mL/min). Lower doses of DOACs were associated with increased overall mortality without a significant decrease in ICH and incident bleeding when compared with standard dose DOACs and warfarin, across all CrCl down to 25 mL/min.¹.

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来源期刊

Journal of the American Board of Family Medicine 医学-医学：内科

CiteScore

4.90

自引率

6.90%

发文量

168

审稿时长

4-8 weeks

期刊介绍： Published since 1988, the Journal of the American Board of Family Medicine ( JABFM ) is the official peer-reviewed journal of the American Board of Family Medicine (ABFM). Believing that the public and scientific communities are best served by open access to information, JABFM makes its articles available free of charge and without registration at www.jabfm.org. JABFM is indexed by Medline, Index Medicus, and other services.