揭示线粒体的奥秘：探索新的tRNA变异在2型糖尿病。

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2025-01-15 DOI:10.4239/wjd.v16.i1.98798

Chun-Han Cheng, Wen-Rui Hao, Tzu-Hurng Cheng

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引用次数: 0

摘要

Ding等人最近的研究为新的线粒体tRNATrp和tRNASer（AGY）变异在2型糖尿病（T2DM）中的功能意义提供了有价值的见解。这篇社论探讨了他们的发现，强调了线粒体功能障碍在T2DM发病机制中的作用。通过研究这些tRNA变异促进疾病进展的分子机制，该研究为治疗策略引入了新的靶点。我们讨论了这些结果的更广泛的含义，强调了理解线粒体遗传学在解决T2DM中的重要性。

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Unveiling mitochondrial mysteries: Exploring novel tRNA variants in type 2 diabetes mellitus.

The recent study of Ding et al provides valuable insights into the functional implications of novel mitochondrial tRNA^Trp and tRNA^Ser(AGY) variants in type 2 diabetes mellitus (T2DM). This editorial explores their findings, highlighting the role of mitochondrial dysfunction in the pathogenesis of T2DM. By examining the molecular mechanisms through which these tRNA variants contribute to disease progression, the study introduces new targets for therapeutic strategies. We discuss the broader implications of these results, emphasizing the importance of understanding mitochondrial genetics in addressing T2DM.

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.