[Cross-sector Management of Medical Treatment and Integrated Forms of Therapy for Post-COVID-19 Patients with Fatigue and Sensorimotor Instability].

For the medical treatment of post-COVID-19 syndrome, only a few cross-sector medical treatment networks, such as the Post-COVIDLMU CONCEPT [1], are currently being implemented. However, no causal therapy can be reliably recommended based on evidence-based criteria. A cross-sector, doctor-led treatment management will be inaugurated for post-COVID-19, initially focusing on the syndrome of fatigue/immunometabolic depression (as a target for precision medicine) and sensorimotor instability as a cognitive parameter. The corresponding parameters will be recorded and analyzed in real time and at the same time become an important environmentally stable training object. The use of internet and mobile-based interventions represents an essential component here.Changes in the leading syndromes of fatigue and sensorimotor instability through stress-controlled standardized training therapy, intensified cognitive behavioral therapy and the process design of interdisciplinary therapy management in compliance with the guidelines of the Federal Joint Committee (G-BA) for cross-professional and cross-sector care for post-COVID-19 patients were the overarching goals of an intervention study at the post-COVID-19-Center Lausitz over a 3-year period (Q1-2021-Q2-2024). The results of a stress-controlled intervention study were integrated into the derivation, design and evaluation of a cross-sector management process. The outcome and management of the training therapy were assessed based on the post-COVID-19 key symptoms and motor fatigue parameters. A secondary psychosomatic syndrome that emerged during treatment was examined using cognitive fatigue parameters.With the stress-controlled sensorimotor intervention integrated into the designed management process as well as intensified cognitive behavioral therapy, improvements in post-COVID-19 key symptoms as well as in the parameters of motor and cognitive fatigability were achieved. The timing of the start of the process stages of the overall management had an influence on the outcome of the treatment path. Intensification of cognitive behavioral therapy also had positive effects, resulting in an increasing level of activity and self control in patients.