在人胸主动脉和主动脉夹层幻象中测量磁共振弹性成像衍生刚度的可行性。

IF 0.7 Q4 SURGERY

Journal of Vascular Surgery Cases Innovations and Techniques Pub Date : 2024-11-30 DOI:10.1016/j.jvscit.2024.101697

Adnan Hirad MD, PhD , Faisal S. Fakhouri PhD , Brian Raterman BS , Ronald Lakony BS , Maxwell Wang MD , Dakota Gonring MD , Baqir Kedwai MD , Arunark Kolipaka PhD , Doran Mix MD

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引用次数: 0

摘要

B型主动脉夹层（TBAD）是一种严重的医疗紧急情况，由胸主动脉、夹层相关动脉瘤（DAA）变性和破裂引起的5年死亡率高达50%。不幸的是，传统的与大小相关的诊断方法无法区分高危daa和稳定daa。我们的目标是使用磁共振弹性成像（MRE）测量DAA刚度作为生物标志物来区分高风险DAA和稳定DAA。这是一项可行性研究，使用MRE(1)制造具有不同刚度的人形几何形状的TBAD模型，(2)用流变法测量TBAD模型的刚度，以及(3)首次成功地将MRE应用于人类志愿者的胸主动脉。具有异质壁刚度的AD模型证明了mre衍生刚度和流变测量刚度之间的相关性。在一名健康志愿者身上进行了初步扫描，以测试该技术在胸主动脉中的可行性。

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Feasibility of measuring magnetic resonance elastography-derived stiffness in human thoracic aorta and aortic dissection phantoms

Type B aortic dissection (TBAD) represents a serious medical emergency with up to a 50% associated 5-year mortality caused by thoracic aorta, dissection-associated aneurysmal (DAA) degeneration, and rupture. Unfortunately, conventional size-related diagnostic methods cannot distinguish high-risk DAAs that benefit from surgical intervention from stable DAAs. Our goal is to use DAA stiffness measured with magnetic resonance elastography (MRE) as a biomarker to distinguish high-risk DAAs from stable DAAs. This is a feasibility study using MRE to (1) fabricate human-like geometries TBAD phantoms with different stiffnesses, (2) measure stiffness in TBAD phantoms with rheometry, and (3) demonstrate the first successful application of MRE to the thoracic aorta of a human volunteer. AD phantoms with heterogenous wall stiffness demonstrated the correlation between MRE-derived stiffness and rheometric measured stiffness. A pilot scan was performed in a healthy volunteer to test the technique's feasibility in the thoracic aorta.

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来源期刊

Journal of Vascular Surgery Cases Innovations and Techniques SURGERY-

CiteScore

1.00

自引率

14.30%

发文量

219

审稿时长

29 weeks

期刊介绍： Journal of Vascular Surgery Cases and Innovative Techniques is a surgical journal dedicated to publishing peer review high quality case reports, vascular images and innovative techniques related to all aspects of arterial, venous, and lymphatic diseases and disorders, including vascular trauma, malformations, wound care and the placement and maintenance of arterio-venous dialysis accesses with an emphasis on the practicing clinician. The Journal seeks to provide novel and timely information to vascular surgeons, interventionalists, phlebologists, wound care specialists, and allied health professionals involved with the management of patients with the entire spectrum of vascular disorders.