不同淋巴结分期系统对儿童肾母细胞瘤生存的预测价值。

IF 1.5 4区医学 Q4 ONCOLOGY

Translational cancer research Pub Date : 2024-12-31 Epub Date: 2024-12-26 DOI:10.21037/tcr-24-959

Songqiang Chen, Zhisheng Wan, Shaohua Hu, Weizhen Bu, Yiqun Lu, Zhenli Zhao

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引用次数: 0

摘要

背景：肾母细胞瘤是最常见的儿童肾癌之一，预后较差。本研究旨在探讨淋巴结（LNs）、阳性淋巴结密度（LND）和阳性淋巴结对数赔率（LODDS）对儿童Wilms肿瘤5年死亡率的预测价值。方法：队列研究从监测、流行病学和最终结果（SEER）数据库中收集了874名Wilms肿瘤患者的数据。采用单因素COX比例风险模型探讨可能的协变量。采用单因素和多因素COX比例风险模型探讨ln、LND、LODDS与Wilms肿瘤患者5年死亡率的相关性。通过一致性和95%置信区间（CI）评估LNs、LND和LODDS对Wilms肿瘤儿童5年死亡率的预测价值。结果：随访5年，804例患者最终存活。结果显示，LND >[危险比(HR) =1.92, 95% CI: 1.01-3.67]和LND≥0.93 （HR =4.87, 95% CI: 2.42-9.81）与5年死亡率风险升高相关，而LODDS≥-0.34 （HR =4.09, 95% CI: 2.18-7.65）与5年死亡率风险升高相关。预测Wilms肿瘤患者5年死亡率的LNs一致性为0.623 （95% CI: 0.566-0.681）。LND和LODDS预测Wilms肿瘤患者5年死亡率的一致性分别为0.623 （95% CI: 0.566-0.681）和0.616 （95% CI: 0.562-0.669）。结论：LODDS对Wilms肿瘤患儿5年死亡率的预测价值与LNs和LND相似。研究结果可能为临床医生鉴别预后不良的患者提供新的工具，并为这些患者提供及时的治疗。

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Prediction values of different lymph nodes staging systems for survival of children with Wilms tumor.

Background: Wilms tumor is one of the most common pediatric kidney cancers with poor prognosis. This study aims to explore the predictive values of lymph nodes (LNs), positive lymph node density (LND) and log odds of positive lymph nodes (LODDS) for the 5-year mortality of children with Wilms tumor.

Methods: The cohort study collected the data of 874 participants with Wilms tumor in the Surveillance, Epidemiology, and End Results (SEER) database. The univariate COX proportional risk model was used to explore the possible covariates. The univariate and multivariable COX proportional risk model were employed for exploring the correlations of LNs, LND, and LODDS with the 5-year mortality of Wilms tumor patients. The predictive values of LNs, LND, and LODDS for the 5-year mortality of children with Wilms tumor were evaluated via concordance and 95% confidence interval (CI).

Results: The follow-up time was 5 years, and 804 participants survived in the end. The results delineated that LND >0 [hazard ratio (HR) =1.92, 95% CI: 1.01-3.67] as well as LND ≥0.93 (HR =4.87, 95% CI: 2.42-9.81) were correlated with increased risk of 5-year mortality while LODDS ≥-0.34 (HR =4.09, 95% CI: 2.18-7.65) was linked with elevated risk of 5-year mortality. The concordance of LNs for predicting the 5-year mortality of Wilms tumor patients was 0.623 (95% CI: 0.566-0.681). The concordances of LND, and LODDS for predicting the 5-year mortality of Wilms tumor patients were 0.623 (95% CI: 0.566-0.681) and 0.616 (95% CI: 0.562-0.669).

Conclusions: The predictive value of LODDS for the 5-year mortality of children with Wilms tumor was similar with LNs and LND. The findings might provide a new tool for helping the clinicians identify those with poor prognosis, and timely treatments should be offered to these patients.

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来源期刊

Translational cancer research ONCOLOGY-

CiteScore

2.10

自引率

0.00%

发文量

252

期刊介绍： Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.