1.5T MR-linacs小场剂量测定校正因子研究。

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Vasiliki Margaroni, Pantelis Karaiskos, Andreas Iosif, Anastasios Episkopakis, Efi Koutsouveli, Eleftherios P Pappas
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引用次数: 0

摘要

目标。1.5 T磁场下的临床剂量测定具有挑战性,更不用说涉及小磁场的情况了。本研究的范围是确定一套相关的校正因子,适用于各种核磁共振兼容的探测器,重点是小领域。本文考虑了文献中采用的两种剂量学形式。在EGSnrc蒙特卡罗代码中模拟了六个小腔电离室(来自三个制造商),四个有源固态探测器和一个热释光剂量计微立方体。使用Unity 1.5 T/7 MV MR-linac (Elekta, UK)的场大小小于1 × 1 cm2的相空间文件作为源模型。模拟计算了kqb、QfB、f(也称为askB、Q)、kQmsrB、fmsrandkQclin、QmsrB、fclin、fmsr与两种不同剂量学形式的相关性。考虑了两个探测器相对于磁场的方向。此外,还研究了电离室柱体长度(一个结构参数)对校正系数的影响。还进行了模拟,以确定在水中获得的校正因子是否可以应用于涉及水等效固体幻影的剂量测定程序。主要的结果。在基于kqb,QfB,f的形式下,即使考虑到最小的场尺寸,电离室响应所需的修正也不超过1.5%。模拟中所包含的有源固态探测器的kqb,QfB,f值范围更广。这是第一个报道电离室qclin,QmsrB,fclin,fmsr值的研究。对于长度大于或等于0.75 cm的长度,茎对校正因子的影响不显著。在水中测定的校正系数也适用于使用固体幻影的剂量学方案。这项工作大大扩展了可用于小场剂量测定的可用探测器的范围,为1.5 T MR-Linacs的调试、光束建模和质量保证程序提供了更多选择。然而,需要更多的研究来建立一个完整可靠的数据集。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
On the correction factors for small field dosimetry in 1.5T MR-linacs.

Objective. Clinical dosimetry in the presence of a 1.5 T magnetic field is challenging, let alone in case small fields are involved. The scope of this study is to determine a set of relevant correction factors for a variety of MR-compatible detectors with emphasis on small fields. Two dosimetry formalisms adopted from the literature are considered.Approach. Six small-cavity ionization chambers (from three manufacturers), four active solid-state detectors and a thermoluminescence dosimeter microcube were modeled in the EGSnrc Monte Carlo code. Phase space files for field sizes down to 1 × 1 cm2of the Unity 1.5 T/7 MV MR-linac (Elekta, UK) were used as source models. Simulations were performed to calculate thekQB,QfB,f(also known askB,Q),kQmsrB,fmsrandkQclin,QmsrB,fclin,fmsrrelevant to two different dosimetry formalisms. Two detector orientations with respect to the magnetic field were considered. Moreover, the effect of the ionization chamber's stem length (a construction parameter) on the correction factor was investigated. Simulations were also carried out to determine whether correction factors obtained in water can be applied in dosimetry procedures involving water-equivalent solid phantoms.Main results. Under thekQB,QfB,f-based formalism, the required corrections to ionization chamber responses did not exceed 1.5% even for the smallest field size considered. A much wider range ofkQB,QfB,fvalues was obtained for the active solid-state detectors included in the simulations. This is the first study to reportkQclin,QmsrB,fclin,fmsrvalues for ionization chambers. The impact of the stem on correction factors is not significant for lengths ⩾0.75 cm. Correction factors determined in water are also valid in dosimetry protocols employing solid phantoms.Significance. This work substantially expands the range of available detectors that can be used in small field dosimetry, enabling more options for commissioning, beam modeling and quality assurance procedures in 1.5 T MR-Linacs. However, more studies are needed to establish a complete and reliable dataset.

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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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