Drug delivery strategies for the treatment of relapse behavior in substance use disorder- A systematic review.

Substance use disorders (SUDs) pose a significant global health challenge, with relapse being a major obstacle in achieving successful treatment outcomes. In recent years, drug delivery strategies have emerged as promising tools to improve treatment efficacy and patient compliance in the context of SUD. Here we explore a diverse range of drug delivery strategies that have been investigated for addressing relapse behavior in SUD. By examining a wide array of clinical and preclinical studies, this review highlights the advances made in drug delivery technologies in the hopes of aiding future research to further establish novel systems. The present systematic review has been created after gathering data from multiple databases including Google Scholar, PubMed and Cochrane, taking into account both review and research (preclinical and clinical) studies along with other systematic reviews and meta-analyses. Relevant articles have been categorized into those pertaining to opioid use disorder, alcohol use disorder and tobacco use disorder. Substance use disorders are a global health problem, with tobacco use associated with the highest mortality, followed by alcohol and opioids. Conventional drug delivery options, such as oral medication have a number of disadvantages, such as low compliance. To tackle these challenges, multiple novel strategies such as sustained release implants, transdermal patches and liquid crystal-based injections have been developed. This systematic review presents a concise view of the strategies already available, as well as those currently undergoing trials. By doing so, the authors hope to stimulate further research to help overcome the challenges in treating SUDs.