Pogo转座子提供了限制癌症生长的工具。

IF 6.6 2区医学 Q1 Biochemistry, Genetics and Molecular Biology

Molecular Oncology Pub Date : 2025-01-15 DOI:10.1002/1878-0261.13801

Elina Zueva, Marianne Burbage

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引用次数: 0

摘要

转座因子为新基因的形成提供了材料。特别是，DNA转座子已经贡献了几个必要的基因参与各种生理或病理条件。在这里，我们讨论了Tu等人在Molecular Cell杂志上的最新发现，他们通过调节核糖体生物发生和限制细胞生长，确定了Pogo转座子衍生基因POGK在三阴性乳腺癌（TNBC）中作为肿瘤抑制因子。TNBC中的异构体开关导致POGK招募表观遗传共抑制因子TRIM28并发挥其抑制功能的能力丧失。这些发现揭示了te衍生基因在为高度恶性TNBC提供新的治疗机会方面的潜力。

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Pogo transposons provide tools to restrict cancer growth.

Transposable elements provide material for novel gene formation. In particular, DNA transposons have contributed several essential genes involved in various physiological or pathological conditions. Here, we discuss recent findings by Tu et al. in Molecular Cell that identify Pogo transposon-derived gene POGK as tumor suppressor in triple-negative breast cancer (TNBC) by regulating ribosome biogenesis and restricting cell growth. An isoform-switch in TNBC results in the loss of POGK capacity to recruit the epigenetic corepressor TRIM28 and to exert its repressive functions. These findings shed light on the potential for TE-derived genes in providing new therapeutic opportunities for highly malignant TNBC.

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来源期刊

Molecular Oncology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

11.80

自引率

1.50%

发文量

203

审稿时长

10 weeks

期刊介绍： Molecular Oncology highlights new discoveries, approaches, and technical developments, in basic, clinical and discovery-driven translational cancer research. It publishes research articles, reviews (by invitation only), and timely science policy articles. The journal is now fully Open Access with all articles published over the past 10 years freely available.