{"title":"儿童维生素D缺乏及其相关因素：中国南方21,811个样本的多中心研究","authors":"Chuican Huang, Sijia Liu, Chen Cheng, Shiyun Chen, Qing Luo, Yan Huang, Yanxian Yao, Xixia Ye, Haizhen Wang, Liangyi Luo, Junwei Xie, Hongai Li, Yumei Duan, Beibei Liu, Wenting Cao, Fangfang Zeng, Wei Xiang, Lichun Fan","doi":"10.3389/ijph.2024.1607411","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prevalence of vitamin D deficiency (VDD) in children/adolescents in extreme southern China.</p><p><strong>Methods: </strong>This multicenter, cross-sectional study included 21,811 children aged 0-18 years from 18 districts in Hainan Province, using a multistage stratified random sampling method from January 2021 to March 2022.</p><p><strong>Results: </strong>Serum 25(OH)D levels decreased with age (p trend <0.001). VDD prevalence increased significantly from 3.7% (95% CI: 3.2, 4.3) in children aged 0-3 years to 43.5% (95% CI: 42.1, 45.0) in those aged 13-18 years. Girls and urban residents showed higher deficiency rates. Adolescents (13-18 years) had the highest prevalence of VDD (43.5%), while toddlers (0-3 years) had the lowest (3.7%). Factors influencing vitamin D status included gender, urban residency, and breastfeeding duration. Seasonal variations showed higher deficiency rates in autumn, particularly among preschoolers. Regional differences were noted, with the highest deficiency in semiarid and subhumid zones for various age groups.</p><p><strong>Conclusion: </strong>A significant increase in VDD with age, particularly among adolescents, urban girls, and during autumn, emphasizing the need for targeted strategies.</p>","PeriodicalId":14322,"journal":{"name":"International Journal of Public Health","volume":"69 ","pages":"1607411"},"PeriodicalIF":2.6000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742945/pdf/","citationCount":"0","resultStr":"{\"title\":\"Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China.\",\"authors\":\"Chuican Huang, Sijia Liu, Chen Cheng, Shiyun Chen, Qing Luo, Yan Huang, Yanxian Yao, Xixia Ye, Haizhen Wang, Liangyi Luo, Junwei Xie, Hongai Li, Yumei Duan, Beibei Liu, Wenting Cao, Fangfang Zeng, Wei Xiang, Lichun Fan\",\"doi\":\"10.3389/ijph.2024.1607411\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the prevalence of vitamin D deficiency (VDD) in children/adolescents in extreme southern China.</p><p><strong>Methods: </strong>This multicenter, cross-sectional study included 21,811 children aged 0-18 years from 18 districts in Hainan Province, using a multistage stratified random sampling method from January 2021 to March 2022.</p><p><strong>Results: </strong>Serum 25(OH)D levels decreased with age (p trend <0.001). VDD prevalence increased significantly from 3.7% (95% CI: 3.2, 4.3) in children aged 0-3 years to 43.5% (95% CI: 42.1, 45.0) in those aged 13-18 years. Girls and urban residents showed higher deficiency rates. Adolescents (13-18 years) had the highest prevalence of VDD (43.5%), while toddlers (0-3 years) had the lowest (3.7%). Factors influencing vitamin D status included gender, urban residency, and breastfeeding duration. Seasonal variations showed higher deficiency rates in autumn, particularly among preschoolers. Regional differences were noted, with the highest deficiency in semiarid and subhumid zones for various age groups.</p><p><strong>Conclusion: </strong>A significant increase in VDD with age, particularly among adolescents, urban girls, and during autumn, emphasizing the need for targeted strategies.</p>\",\"PeriodicalId\":14322,\"journal\":{\"name\":\"International Journal of Public Health\",\"volume\":\"69 \",\"pages\":\"1607411\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-01-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742945/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Public Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/ijph.2024.1607411\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/ijph.2024.1607411","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China.
Objective: To investigate the prevalence of vitamin D deficiency (VDD) in children/adolescents in extreme southern China.
Methods: This multicenter, cross-sectional study included 21,811 children aged 0-18 years from 18 districts in Hainan Province, using a multistage stratified random sampling method from January 2021 to March 2022.
Results: Serum 25(OH)D levels decreased with age (p trend <0.001). VDD prevalence increased significantly from 3.7% (95% CI: 3.2, 4.3) in children aged 0-3 years to 43.5% (95% CI: 42.1, 45.0) in those aged 13-18 years. Girls and urban residents showed higher deficiency rates. Adolescents (13-18 years) had the highest prevalence of VDD (43.5%), while toddlers (0-3 years) had the lowest (3.7%). Factors influencing vitamin D status included gender, urban residency, and breastfeeding duration. Seasonal variations showed higher deficiency rates in autumn, particularly among preschoolers. Regional differences were noted, with the highest deficiency in semiarid and subhumid zones for various age groups.
Conclusion: A significant increase in VDD with age, particularly among adolescents, urban girls, and during autumn, emphasizing the need for targeted strategies.
期刊介绍：
The International Journal of Public Health publishes scientific articles relevant to global public health, from different countries and cultures, and assembles them into issues that raise awareness and understanding of public health problems and solutions. The Journal welcomes submissions of original research, critical and relevant reviews, methodological papers and manuscripts that emphasize theoretical content. IJPH sometimes publishes commentaries and opinions. Special issues highlight key areas of current research. The Editorial Board''s mission is to provide a thoughtful forum for contemporary issues and challenges in global public health research and practice.
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