大自然的魔力:天然产物如何与线粒体携手治疗中风。

IF 4.4 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Frontiers in Pharmacology Pub Date : 2025-01-07 eCollection Date: 2024-01-01 DOI:10.3389/fphar.2024.1434948
Lin Cheng, Shangbin Lv, Chengkai Wei, Sucheng Li, Hao Liu, Yong Chen, Zhaoliang Luo, Hongyan Cui
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引用次数: 0

摘要

背景:线粒体作为细胞的能量工厂,参与细胞分化、信号转导、细胞周期、细胞凋亡等一系列重要活动,同时也调节细胞生长。然而,目前中风的药物治疗受到诸如耐药性和副作用等问题的挑战,需要探索新的治疗策略。目的:综述靶向线粒体的天然化合物对神经元线粒体功能和代谢的调控作用,为脑卒中治疗提供新的视角。主要发现:大量体外和体内研究表明,小檗碱、人参皂苷、黄芩苷等天然产物通过多种机制保护神经元线粒体功能,减轻脑卒中引起的损伤。这些化合物通过调节线粒体相关凋亡蛋白的表达来减少神经元凋亡。它们抑制线粒体通透性过渡孔(mPTP)的激活,从而减少ROS的产生和细胞色素C的释放,这有助于保持线粒体功能。此外,它们调节铁下垂、线粒体分裂,促进线粒体自噬和运输,进一步增强神经元的保护作用。结论:天然产物作为一种多靶点的化学制剂,具有疗效高、副作用少的特点,在脑卒中创新治疗中具有广阔的应用前景。未来的研究应进一步研究这些天然产物在临床应用中的有效性和安全性,推动其作为脑卒中治疗新策略的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nature's magic: how natural products work hand in hand with mitochondria to treat stroke.

Background: Mitochondria, as the energy factories of cells, are involved in a wide range of vital activities, including cell differentiation, signal transduction, the cell cycle, and apoptosis, while also regulating cell growth. However, current pharmacological treatments for stroke are challenged by issues such as drug resistance and side effects, necessitating the exploration of new therapeutic strategies.

Objective: This review aims to summarize the regulatory effects of natural compounds targeting mitochondria on neuronal mitochondrial function and metabolism, providing new perspectives for stroke treatment.

Main findings: Numerous in vitro and in vivo studies have shown that natural products such as berberine, ginsenosides, and baicalein protect neuronal mitochondrial function and reduce stroke-induced damage through multiple mechanisms. These compounds reduce neuronal apoptosis by modulating the expression of mitochondrial-associated apoptotic proteins. They inhibit the activation of the mitochondrial permeability transition pore (mPTP), thereby decreasing ROS production and cytochrome C release, which helps preserve mitochondrial function. Additionally, they regulate ferroptosis, mitochondrial fission, and promote mitochondrial autophagy and trafficking, further enhancing neuronal protection.

Conclusion: As multi-target chemical agents, natural products offer high efficacy with fewer side effects and present promising potential for innovative stroke therapies. Future research should further investigate the effectiveness and safety of these natural products in clinical applications, advancing their development as a new therapeutic strategy for stroke.

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来源期刊
Frontiers in Pharmacology
Frontiers in Pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
7.80
自引率
8.90%
发文量
5163
审稿时长
14 weeks
期刊介绍: Frontiers in Pharmacology is a leading journal in its field, publishing rigorously peer-reviewed research across disciplines, including basic and clinical pharmacology, medicinal chemistry, pharmacy and toxicology. Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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