噪声和代谢代价对皮层任务表征的影响。

IF 6.4 1区 生物学 Q1 BIOLOGY
eLife Pub Date : 2025-01-21 DOI:10.7554/eLife.94961
Jake Patrick Stroud, Michal Wojcik, Kristopher Torp Jensen, Makoto Kusunoki, Mikiko Kadohisa, Mark J Buckley, John Duncan, Mark G Stokes, Mate Lengyel
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引用次数: 0

摘要

认知灵活性既需要对任务相关刺激进行编码,也需要对任务无关刺激进行忽略。虽然对任务相关刺激的神经编码越来越了解,但对忽略任务无关刺激的机制仍然知之甚少。在这里,我们研究了任务表现和生物约束如何共同决定神经回路中相关和不相关刺激的编码。通过数学分析和任务优化的递归神经网络,我们发现神经回路可以根据神经噪声的强度和代谢成本表现出一系列的代表性几何形状。通过将这些结果与灵长类动物前额叶皮层(PFC)在学习过程中的记录进行比较,我们发现PFC的神经活动变化与最小表征策略一致。具体来说,我们的分析表明,动态无关刺激的抑制是通过活动沉默,亚阈值动态实现的。我们的结果提供了一个规范性的解释,为什么PFC实现一个自适应的,最小的表征策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of noise and metabolic cost on cortical task representations.

Cognitive flexibility requires both the encoding of task-relevant and the ignoring of task-irrelevant stimuli. While the neural coding of task-relevant stimuli is increasingly well understood, the mechanisms for ignoring task-irrelevant stimuli remain poorly understood. Here, we study how task performance and biological constraints jointly determine the coding of relevant and irrelevant stimuli in neural circuits. Using mathematical analyses and task-optimized recurrent neural networks, we show that neural circuits can exhibit a range of representational geometries depending on the strength of neural noise and metabolic cost. By comparing these results with recordings from primate prefrontal cortex (PFC) over the course of learning, we show that neural activity in PFC changes in line with a minimal representational strategy. Specifically, our analyses reveal that the suppression of dynamically irrelevant stimuli is achieved by activity-silent, sub-threshold dynamics. Our results provide a normative explanation as to why PFC implements an adaptive, minimal representational strategy.

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来源期刊
eLife
eLife BIOLOGY-
CiteScore
12.90
自引率
3.90%
发文量
3122
审稿时长
17 weeks
期刊介绍: eLife is a distinguished, not-for-profit, peer-reviewed open access scientific journal that specializes in the fields of biomedical and life sciences. eLife is known for its selective publication process, which includes a variety of article types such as: Research Articles: Detailed reports of original research findings. Short Reports: Concise presentations of significant findings that do not warrant a full-length research article. Tools and Resources: Descriptions of new tools, technologies, or resources that facilitate scientific research. Research Advances: Brief reports on significant scientific advancements that have immediate implications for the field. Scientific Correspondence: Short communications that comment on or provide additional information related to published articles. Review Articles: Comprehensive overviews of a specific topic or field within the life sciences.
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